Evidence map›Paper›PMID 42087906›Full record

ArticleMedComm2026

Discovery of 4-Quinazolinone-Containing Phenylalanine Derivatives as Potent, Resistant-Tolerant HIV Capsid Inhibitors.

Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu and 9 more

Abstract read
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xujie ZhangDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.ORCID https://orcid.org/0000-0003-1393-4665
Lin SunDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.
Laura WalshamSchool of Biological Sciences University of Auckland Auckland New Zealand.
Yuexi MaDepartment of Microbiology and Infectious Disease Research Center School of Basic Medical Sciences Peking University Health Science Center Beijing China.
Dang DingDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.
Mei WangDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.
Fabao ZhaoDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.
Jian ZhangDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.
Zhao WangDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.
Shujing XuDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.
Xiangyi JiangDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.
Yang ZhouDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.
Erik De ClercqRega Institute for Medical Research Laboratory of Virology and Chemotherapy K.U. Leuven Leuven Belgium.
Christophe PannecouqueRega Institute for Medical Research Laboratory of Virology and Chemotherapy K.U. Leuven Leuven Belgium.
Chin-Ho ChenSurgical Oncology Research Facility Duke University Medical Center Durham North Carolina USA.
David C GoldstoneSchool of Biological Sciences University of Auckland Auckland New Zealand.
Xinyong LiuDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.
Alexej DickDepartment of Biochemistry & Molecular Biology Drexel University College of Medicine Philadelphia Pennsylvania USA.
Peng ZhanDepartment of Medicinal Chemistry School of Pharmaceutical Sciences Key Laboratory of Chemical Biology (Ministry of Education) Shandong University Jinan Shandong China.

Funding

Novel anti-HIV compounds targeting the HIV-1 matrix proteinR01AI150491 · NIAID · DREXEL UNIVERSITY · PI LOLL, PATRICK J · 2020 to 2022
$1.7M
NIAID NIH HHS R01 AI150491
6 · The paper itself

Abstract

The HIV-1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle. Using structure-based strategy, we designed and synthesized a series of phenylalanine derivatives containing a 4-quinazolinone scaffold as novel HIV-1 CA inhibitors. Among them,

Indexed as

4‐quinazolinonedrug designHIV‐1 capsidlong‐acting drugsphenylalanine derivatives

Identifiers

PMID42087906
PMCPMC13136073

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.