ArticleThe Journal of international medical research2026
The real diagnostic value of serum iron in iron deficiency anemia among patients with inflammatory bowel disease: A retrospective study.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveThe diagnostic utility of serum iron in identifying iron deficiency anemia among patients with inflammatory bowel disease remains underreported. This study aimed to evaluate the true diagnostic value of serum iron.MethodsA total of 160 patients with iron deficiency anemia from a grade-A general hospital in Sichuan Province between January 2022 and January 2025 were enrolled. Eighty patients with inflammatory bowel disease and iron deficiency anemia were included in the test group, while 80 patients with iron deficiency anemia without inflammation were included in the control group. Iron metabolism parameters, including serum iron and serum ferritin, complete blood count indices, and biochemical markers, were collected and compared. Differences in diagnosing iron deficiency anemia using serum iron and serum ferritin among patients with inflammatory bowel disease were compared using the chi-square test. Spearman correlation analysis was performed among serum iron, serum ferritin, and other indicators. Meanwhile, potential factors affecting serum iron levels were investigated using linear regression, and the significance of serum iron in diagnosing inflammatory bowel disease with iron deficiency was evaluated using the receiver operating characteristic curve.ResultsAmong patients with inflammatory bowel disease, ulcerative colitis and Crohn's disease showed no significant differences in serum iron and serum ferritin levels. The real clinical results showed that when using 1-6.6 times the lower limit of normal of serum ferritin as a threshold to diagnose patients with inflammatory bowel disease and iron deficiency anemia, a statistically significant difference was observed compared with the serum iron lower limit of 1 time (p
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