Evidence map›Paper›PMID 42087564›Full record

ArticleNucleic acids research2026

T2T-Hub: a central platform for analyzing plant and animal telomere-to-telomere genomes.

Haoyu Chao, Zhonghao Ruan, Zhuojin Li, Xinkai Zhou, Shilong Zhang, Xingxing Shen, Cong Feng, Dijun Chen, Ming Chen

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haoyu ChaoDepartment of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-5475-0443
Zhonghao RuanKey Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.ORCID 0009-0003-1908-3168
Zhuojin LiKey Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.ORCID 0000-0002-4309-9798
Xinkai ZhouKey Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.ORCID 0000-0001-8791-294X
Shilong ZhangDepartment of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-5823-5721
Xingxing ShenZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-5765-1419
Cong FengDepartment of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-4699-8801
Dijun ChenKey Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.ORCID 0000-0002-7456-2511
Ming ChenDepartment of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-9677-1699

Funding

National Key Research and Development Program of China 2023YFE0112300National Key Research and Development Program of China 2025YFE0151900National Natural Science Foundation of China 32070656National Natural Science Foundation of China 32261133526National Natural Science Foundation of China 32270709National Natural Science Foundation of China 32300532National Natural Science Foundation of China 32570787
6 · The paper itself

Abstract

T2T-Hub is a free, web-based platform designed to facilitate the analysis and visualization of telomere-to-telomere (T2T) genomes in plants and animals. The server integrates automated structural and functional annotation workflows with interactive visualization and comparative analysis tools, enabling systematic exploration of complete genome assemblies. T2T-Hub provides a standardized and unified analytical framework specifically tailored for T2T genomes, enabling consistent and comparable analyses across species. To ensure robustness and comparability, we uniformly analyzed 230 high-quality plant and 39 animal T2T genomes using the same standardized workflows, providing users with a consistent reference framework. Users can upload assembled T2T genome sequences together with gene annotation files (GFF3), which are automatically validated and processed through unified analyses including genome quality assessment, telomere and centromere identification, transcription factor prediction, functional annotation, and interactive genome visualization. Importantly, the platform enables interactive genome browsing, searching, and result sharing without requiring any programming skills, thereby lowering the barrier for T2T genome analysis. For internally curated genomes, T2T-Hub additionally provides repeat and noncoding RNA annotation, comparative genomics analyses, and integrated online tools. The platform is freely accessible without login at https://bis.zju.edu.cn/t2thub and https://biobigdata.nju.edu.cn/t2thub.

Indexed as

GenomeGenome, PlantGenomicsSoftwareTelomereAnimalsCentromereInternetMolecular Sequence AnnotationPlants

Identifiers

PMID42087564
PMCPMC13355076

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.