ArticlePlant, cell & environment2026
Protease-Mediated Dual Action Against Rice Blast: Suppression of Magnaporthe oryzae Ergosterol Biosynthesis Pathway and Enhancement of Rice Disease Resistance by Bacillus amyloliquefaciens SN16-1.
Article in Plant, cell & environment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Rice blast, caused by the fungal pathogen Magnaporthe oryzae, poses a severe threat to global rice production. While biological control represents a promising sustainable strategy, the molecular mechanisms by which biocontrol agents suppress M. oryzae remain poorly understood. Our findings elucidate a novel mechanism of bacterial biocontrol, wherein a secreted bacterial protease modulates fungal signalling pathways to disrupt its environmental fitness and pathogenic structures, while enhancing host resistance to blast disease. We demonstrate that the Bacillus amyloliquefaciens SN16-1 exhibits antagonistic activity against M. oryzae Guy11. Integrated dual RNA sequencing and protein-protein interaction analysis revealed that the ergosterol biosynthesis pathway in M. oryzae is crucial for its pathogenicity and is markedly suppressed during co-culture with SN16-1. We identified MoERG1, a key enzyme in this pathway, as essential for fungal development and virulence. Further analysis showed that the serine protease AprE, secreted by SN16-1, is a critical mediator. AprE triggers the Hog1-MAPK signalling cascade in M. oryzae, leading to transcriptional repression of ergosterol biosynthesis genes, concomitant activation of plant disease resistance, and induction of ROS accumulation, hyperosmotic stress and apoptosis in fungal hyphae. This study provides new insights into host-microbe-pathogen interactions and offers an effective strategy for developing targeted biocontrol solutions against devastating plant diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.