Evidence map›Paper›PMID 42087518›Full record

ArticleCell adhesion & migration2026

Dynamic modulation of intercellular adhesion mediated by matriptase-EPCAM/Trop-2 axes is critical for cell extrusion, division, and collective migration.

Yu-Ling A Kao, Qiaochu Wang, Dajun D Lu, Shigeki Umemura, Vivien Lee, Ying Hsuan Tsai, Robert B Barndt, Jehng-Kang Wang, Michael D Johnson, Chen-Yong Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell adhesion & migration, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu-Ling A KaoLombardi Comprehensive Cancer Center, Department of Oncology, Medical Center, Georgetown University, Washington, DC, USA.
Qiaochu WangLombardi Comprehensive Cancer Center, Department of Oncology, Medical Center, Georgetown University, Washington, DC, USA.
Dajun D LuLombardi Comprehensive Cancer Center, Department of Oncology, Medical Center, Georgetown University, Washington, DC, USA.
Shigeki UmemuraDepartment of Thoracic Oncology, National Cancer Center Hospital East, Bunkyo-ku, Japan.
Vivien LeeSchool of Medicine, National Yang Ming Chiao Tung University, Yangming Campus, Taipei, Taiwan.
Ying Hsuan TsaiSchool of Medicine, National Defense Medical University, Taipei, Taiwan.
Robert B BarndtLombardi Comprehensive Cancer Center, Department of Oncology, Medical Center, Georgetown University, Washington, DC, USA.
Jehng-Kang WangDepartment of Biochemistry, National Defense Medical University, Taipei, Taiwan.
Michael D JohnsonLombardi Comprehensive Cancer Center, Department of Oncology, Medical Center, Georgetown University, Washington, DC, USA.
Chen-Yong LinLombardi Comprehensive Cancer Center, Department of Oncology, Medical Center, Georgetown University, Washington, DC, USA.

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
NCI NIH HHS P30 CA051008
6 · The paper itself

Abstract

Epithelial dynamics require rapid remodeling of cell adhesion during extrusion, division, and migration. We identify a matriptase-dependent mechanism regulating the Ca

Indexed as

Antigens, NeoplasmCell Adhesion MoleculesCell DivisionCell MovementEpithelial Cell Adhesion MoleculeSerine EndopeptidasesAnimalsCell AdhesionHumansAntigens, NeoplasmCell Adhesion MoleculesEpithelial Cell Adhesion MoleculematriptaseSerine EndopeptidasesTACSTD2 protein, humanCell adhesioncell divisioncell extrusioncollective migrationEpCAMmatriptaseTrop-2

Identifiers

PMID42087518
PMCPMC13154952

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.