Evidence map›Paper›PMID 42087449›Full record

ArticleScandinavian journal of medicine & science in sports2026

Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health: Insights from a Genome-Wide Polygenic Score for Cardiorespiratory Fitness in the FinnGen and HUNT cohorts.

L Joensuu, V Lukander, P Herranen, N P Tynkkynen, U Kujala, R Lopéz-Bueno, A N Nordeidet, M Klevjer, K Øvretveit, U Wisløff and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scandinavian journal of medicine & science in sports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

L JoensuuGerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.ORCID https://orcid.org/0000-0002-9544-6552
V LukanderInstitute for Molecular Medicine Finland, HiLIFE, Helsinki, Finland.ORCID https://orcid.org/0009-0009-8017-3502
P HerranenGerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.ORCID https://orcid.org/0000-0002-4539-327X
N P TynkkynenGerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.ORCID https://orcid.org/0000-0001-8245-1275
U KujalaFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.ORCID https://orcid.org/0000-0002-9262-1992
R Lopéz-BuenoFaculty of Health Sciences, Public University of Navarra, Pamplona, Spain.ORCID https://orcid.org/0000-0002-7865-3429
A N NordeidetDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0001-7742-5822
M KlevjerDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0001-8372-276X
K ØvretveitDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0002-5528-0674
U WisløffDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0002-7211-3587
A ByeDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0003-1259-5542
U EkelundNorwegian School of Sport Sciences, Oslo, Norway.ORCID https://orcid.org/0000-0003-2115-9267
M OllikainenInstitute for Molecular Medicine Finland, HiLIFE, Helsinki, Finland.ORCID https://orcid.org/0000-0003-3661-7400
FinnGen
E SillanpääFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.ORCID https://orcid.org/0000-0001-6375-959X

Funding

iCANDOC Doctoral Education Pilot in Precision Cancer Medicine, University of HelsinkiJuho Vainio FoundationPäivikki and Sakari Sohlberg FoundationResearch Council of Finland 341750Research Council of Finland 346509Research Council of Finland 361981
6 · The paper itself

Abstract

We evaluated how much cardiorespiratory fitness (CRF)-related genetics contribute to the risk of common noncommunicable diseases (NCDs) and mortality, and whether individuals with different levels of CRF and genetic predispositions differ in health characteristics. We used a validated SBayesR-based genome-wide polygenic score, leveraging information from 905 707 single-nucleotide polymorphisms, to measure CRF genetics (PGS CRF). Associations with register-based incident NCDs and mortality were analyzed using Cox proportional hazards models in the FinnGen cohort (N = 262 137; 53.5-years at baseline, 52.0% women) and replicated in the HUNT3 cohort (N = 26 115; 59.0-years, 52.4% women). In HUNT3, we also compared the health characteristics of individuals having age- and sex-specific high or low CRF (V̇O

Indexed as

Cardiorespiratory FitnessNoncommunicable DiseasesAgedCardiovascular DiseasesCohort StudiesFemaleFinlandGenetic Predisposition to DiseaseGenetic Risk ScoreGenome-Wide Association StudyHumansHypertensionMaleMiddle AgedOxygen ConsumptionPolymorphism, Single Nucleotide

Identifiers

PMID42087449
PMCPMC13145328

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.