ArticleMagnetic resonance in medicine2026
MR Spectroscopy Without Water Suppression Using the Gradient Impulse Response Function.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Measuring the vibrational response of a high performance gradient coil.Magnetic resonance imaging · 2026Article
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3 authors.
Funding
Abstract
purposeNon-water-suppressed proton spectroscopy, THEORY AND
methodsThe Gradient Impulse Response Function (GIRF) was used to predict time-dependent magnetic field perturbations during the FID that generate the artefactual sidebands. The GIRF was measured in a one-time calibration, independent of spectroscopy acquisitions, enabling post-processing correction of the sidebands without sequence modification or additional dedicated hardware. GIRF-corrected non-water-suppressed single-voxel-spectroscopy (SVS) was compared to otherwise identical water-suppressed acquisitions in eight participants at 3T using semi-LASER and MEGA-PRESS sequences.
resultsAcross participants, GIRF correction reduced sideband amplitudes to levels comparable with the spectral baseline, enabling recovery of the underlying metabolite signals. Systematic increases in quantified metabolite concentrations were observed relative to water-suppressed acquisitions, consistent with water-suppression-induced magnetization transfer effects. Total creatine exhibited the largest increase, with enhancement ratios of 1.069 ± 0.039 for MEGA-PRESS and 1.535 ± 0.160 for semi-LASER acquisitions.
conclusionGradient-induced artefactual sidebands in non-water-suppressed MR spectroscopy can be effectively corrected using the GIRF to predict time-dependent magnetic field perturbations during the FID. In principle, the approach extends to other SVS sequences and field strengths following appropriate GIRF calibration.
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