Evidence map›Paper›PMID 42087390›Full record

ArticleDevelopmental science2026

The Role of Early Visual Experience in Cross-Signal Dependency Detection.

Priti Gupta, Lukas Vogelsang, Marin Vogelsang, Neil Khemani, Manvi Jain, Naviya Lall, Dhun Verma, Chetan Ralekar, Suma Ganesh, Pawan Sinha

Abstract read
In one paragraph

Article in Developmental science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Intact Visual Correlation Detection in Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Priti GuptaBoston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-9575-9658
Lukas VogelsangDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Marin VogelsangDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Neil KhemaniDepartment of Computer Science, Stanford University, California, USA.
Manvi JainDepartment of Humanities and Social Sciences, Indian Institute of Technology Delhi, Delhi, India.ORCID https://orcid.org/0000-0002-6531-1905
Naviya LallProject Prakash, Dr Shroff's Charity Eye Hospital, New Delhi, Delhi, India.
Dhun VermaProject Prakash, Dr Shroff's Charity Eye Hospital, New Delhi, Delhi, India.
Chetan RalekarDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Suma GaneshDepartment of Pediatric Ophthalmology, Dr Shroff's Charity Eye Hospital, New Delhi, Delhi, India.
Pawan SinhaDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Funding

Project Prakash: Development of Object Perception After Late Sight OnsetR01EY020517 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SINHA, PAWAN · 2011 to 2025
$8.9M
Fulbright-Nehru Academic and Professional Excellence Visiting Scholar Program of the United States - India Educational Foundation and the US Department of StateHallis FoundationJapan Society for the Promotion of ScienceNational Eye Institute (NIH)NEI NIH HHS R01 EY020517Nick Simons FoundationRIST foundationSikand foundationSimons Center for the Social Brain, Massachusetts Institute of TechnologyUnited States - India Educational FoundationYamada Science Foundation
6 · The paper itself

Abstract

Temporal co-occurrence of two sensory signals is a powerful indicator of their potential association. Detection of such coincidences is believed to be a key contributor to perceptual organization and a primary objective of cortical computations. Here, we investigate whether the development of this ability requires early sensory experience. We examined the performance of early-blind children who surgically gained sight as adolescents. Our data revealed three key results. First, we found that while not fully reaching the level of normally sighted controls, late-sighted patients examined several years after surgery were able to robustly detect signal dependencies with markedly above-chance accuracy at all but the weakest strengths tested. Second, for both groups, performance levels were comparable for intra- and inter-modal stimuli, revealing significant plasticity for establishing cross-modal linkages late in childhood. Finally, comparison with a separate group of late-sighted patients tracked longitudinally from preoperative to one-month postoperative status suggests that this ability may follow a protracted developmental time course after sight surgery. These results help characterize the development of a foundational process for detecting relationships between environmental entities and point to the resilience of acquiring this important skill to early-onset, prolonged visual deprivation. SUMMARY: We tested the ability of congenitally blind children who gained sight late in childhood to detect repeated temporal co-occurrence of sensory signals. We found that while not reaching the full normally sighted level, late-sighted patients are able to detect signal dependencies with markedly above-chance accuracy. This ability may follow a protracted developmental time course after sight-restoring surgery. The availability of neural plasticity into late childhood has important implications for the rehabilitation prospects of children with congenital blindness.

Indexed as

BlindnessSignal Detection, PsychologicalVisual PerceptionAdolescentChildFemaleHumansMaleNeuronal PlasticityPhotic Stimulationcongenital blindnesscorrelation detectionlate sight onsettemporal coincidencesvisual development

Identifiers

PMID42087390
PMCPMC13144708

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.