ArticleJournal of the American Chemical Society2026
Role of 2-Hydroxyimines in Chiral Phosphoric Acid-Catalyzed Mannich-Type Reactions: Enhancing Reactivity and Selectivity via Dimerization.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Chiral phosphoric acids (CPAs) have emerged as versatile catalysts for asymmetric catalysis, capable of transforming a wide selection of substrates with high stereoselectivities. However, the mechanistic role of higher aggregates in CPA-catalyzed reactions remains poorly understood, although increasing evidence suggests that dimeric and trimeric CPA species can promote challenging transformations. This work provides comprehensive experimental evidence demonstrating that special [CPA/imine]
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