ArticleJNCI cancer spectrum2026
Psychosocial factors and overall mortality after prostate cancer diagnosis among predominantly low-income Black and White adults.
Article in JNCI cancer spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPsychosocial factors may influence prostate cancer (PCa) survival, but evidence is limited for low-income populations.
methodsThis study used data from the Southern Community Cohort Study (SCCS), a prospective cohort of ∼85 000 individuals aged 40-79, from predominantly low-income backgrounds, enrolled between 2002 and 2009 across 12 southeastern states. A total of 1367 men (1058 Black and 309 White) developed PCa during the follow-up of 34 313 men were included. The Kaplan-Meier method was used to generate 5-year survival rates with log-rank tests for statistical significance. Multivariable Cox models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for psychosocial-mortality associations.
resultsOver 18 years of follow-up, 291 Black (27.5%) and 59 White (19.1%) PCa patients died (P = .03). White men self-reporting major depressive symptoms and their inability to control important things in life (ITC) had an 11% (Psurvival = .01) and 12% (Psurvival = .01) lower 5-year survival compared with those who did not, with aHR of 2.56, (95% CI = 1.13 to 5.77) and 2.30 (95% CI = 1.07 to 4.95), respectively. Inverse associations were found for per SD increase in depression score (aHR = 0.84, 95% CI = 0.74 to 0.96) among Black patients. Testing for multiplicative interaction was significant for race-depression (Pinteraction = .02) and race-ITC (Pinteraction = .04). The associations were mainly seen among PCa cases diagnosed within 5 years after baseline survey.
conclusionPsychosocial-mortality associations among PCa patients are complex and may not affect individuals equally. Programs aiming to reduce mortality for individuals with PCa should consider their psychosocial needs and demographic background.
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