Impact of intraoperative nonsteroidal anti-inflammatory drugs on acute kidney injury after major noncardiac surgery: a propensity score-matched analysis.

Cong Zhang, Yixin Liao, Xiaoyu Zhu, Wei Wang, Xinxin Liao

Abstract read

In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cong ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Anesthesiology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.

Yixin LiaoDepartment of Obstetrics and Gynecology, Centre for Reproductive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Xiaoyu ZhuDepartment of Anesthesiology, Guangdong Provincial Key Laboratory of Precision Anesthesia and Perioperative Organ Protection, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Wei WangDepartment of Anesthesiology, Guangdong Provincial Key Laboratory of Precision Anesthesia and Perioperative Organ Protection, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Xinxin LiaoDepartment of Anesthesiology, Guangdong Provincial Key Laboratory of Precision Anesthesia and Perioperative Organ Protection, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as part of multimodal analgesia, but their association with acute kidney injury (AKI) in patients undergoing elective surgery remains uncertain. We conducted a retrospective, propensity score-matched study at a single-center academic hospital (ChiCTR2300076725). The primary outcome was the incidence of AKI, defined by the Kidney Disease: Improving Global Outcomes (KDIGO) serum creatinine criteria, compared between patients who did and did not receive NSAIDs during surgery. Secondary outcomes included AKI severity staging and prolonged postoperative hospitalization (≥7 days). A total of 11,139 patients were included, with 3,361 in the NSAIDs group and 7,778 in the control group. After propensity score matching (PSM), 3,361 matched pairs were obtained. The incidence of postoperative AKI was comparable between the NSAIDs and control groups after matching (4.2%

Indexed as

Acute Kidney InjuryAnti-Inflammatory Agents, Non-SteroidalElective Surgical ProceduresPostoperative ComplicationsAgedCreatinineFemaleHumansIncidenceLength of StayLogistic ModelsMaleMiddle AgedPropensity ScoreRetrospective StudiesRisk FactorsAnti-Inflammatory Agents, Non-SteroidalCreatinineAcute kidney injurymajor noncardiac surgeryNSAIDspropensity score matching

Identifiers

PMID42087275

DOI10.1080/0886022X.2026.2663247

PMCPMC13148088

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.