Evidence map›Paper›PMID 42087247›Full record

ArticleJournal of animal science and biotechnology2026

Runs of homozygosity reveal population dynamics and selection across global cattle.

Jun Ma, Xinxia Liu, Xue Gao, Dawei Wei, Zijing Zhang, Abdullah Muhammad, Ningbo Chen, Xiaoting Xia, Yun Ma, Eryao Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jun MaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.
Xinxia LiuCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.
Xue GaoInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100091, People's Republic of China.
Dawei WeiCollege of Animal Science and Technology, Ningxia University, Yinchuan, Ningxia, 750021, People's Republic of China.
Zijing ZhangInstitute of Animal Husbandry, Henan Academy of Agricultural Sciences, Zhengzhou, Henan, 450002, People's Republic of China.
Abdullah MuhammadCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.
Ningbo ChenCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.
Xiaoting XiaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.
Yun MaCollege of Animal Science and Technology, Ningxia University, Yinchuan, Ningxia, 750021, People's Republic of China.
Eryao WangInstitute of Animal Husbandry, Henan Academy of Agricultural Sciences, Zhengzhou, Henan, 450002, People's Republic of China.
Xian LiuHenan Provincial Livestock Technology Promotion Station, Zhengzhou, Henan, 450008, People's Republic of China.
Chuzhao LeiCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.
Yu JiangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.
Yongzhen HuangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China. hyzsci@nwafu.edu.cn.

Funding

Breeding and production of cattle and sheep by scientific and technological innovation team of Henan Academy of Agricultural Sciences 2023TD25China Agriculture Research System of MOF and MARA CARS-37Henan Beef Cattle Industrial Technology System HARS-22-13-SKey R&D Program of Ningxia 2024BBF01007Major Science and Technology Projects in Henan Province 221100110200National Natural Science Foundation of China 32573186Natural Science Foundation of Henan 252300420687State Key Laboratory of Rail Traffic Control and Safety 2024BBF01007STI2030-Major Projects 2023ZD040480206
6 · The paper itself

Abstract

backgroundCattle have undergone complex evolutionary trajectories shaped by domestication, migration, and selection. Although runs of homozygosity (ROH) are a ubiquitous genomic feature, their full potential to decipher the evolutionary history and functional consequences in global cattle populations remains underexplored. We analyzed whole-genome sequences from 102 breeds across 17 geographic regions to conduct a global investigation of ROH landscapes, population structure, genomic inbreeding, and functional variants.

resultsROH patterns revealed elevated homozygosity burdens in intensively selected European breeds, whereas South Chinese indicine showed a high short ROH burden, suggestive of a unique ancient demography. ROH-based principal component analysis (PCA) and admixture delineated taurine-indicine lineages, region-specific ancestries, inbreeding, and breeding effects. ROH-based inbreeding coefficient (F

conclusionThis study establishes ROH as a pivotal genomic marker for illuminating the dynamics of domestication, migration, inbreeding, and selection. Our findings offer valuable resources and insights for advancing genetic conservation and precision breeding in cattle under the pressures of climate change.

Indexed as

CattleInbreeding coefficientsPopulation dynamicsROH hotspotsRuns of homozygosity

Identifiers

PMID42087247
PMCPMC13147640

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.