Evidence map›Paper›PMID 42087241›Full record

ArticleEpigenetics & chromatin2026

Host-cell dependent epigenetic profiles associated with survival outcomes in T. gondii infection.

Loic Ciampossin, Arzu Ulu, Todd Lenz, Zehao Li, Steven Abel, Sandeep Srivastava, Michael White, Emma Wilson, Karine G Le Roch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics & chromatin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Loic CiampossinDepartment of Molecular, Cell and Systems Biology, University of California Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Arzu UluDivision of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Todd LenzDepartment of Molecular, Cell and Systems Biology, University of California Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Zehao LiDepartment of Molecular, Cell and Systems Biology, University of California Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Steven AbelDepartment of Molecular, Cell and Systems Biology, University of California Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Sandeep SrivastavaDivision of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Michael WhiteDivision of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Emma WilsonDivision of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Karine G Le RochDepartment of Molecular, Cell and Systems Biology, University of California Riverside, 900 University Avenue, Riverside, CA, 92521, USA. karine.leroch@ucr.edu.

Funding

Defining the cell and molecular basis of Toxoplasma recrudescenceR01AI158417 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WHITE, MICHAEL W, WILSON, EMMA H · 2021 to 2025
$3.5M
Evolution of the 3D chromatin structure in apicomplexan parasitesR21AI142506 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2019 to 2020
$479k
NIAID NIH HHS R01 AI158417NIAID NIH HHS R21 AI142506University of California, Riverside NIFA-Hatch-225935
6 · The paper itself

Abstract

Toxoplasmosis is a widespread parasitic disease affecting roughly one-third of the global population. In immunocompromised individuals or during pregnancy, infection can result in severe complications. Following primary infection, Toxoplasma gondii forms dormant bradyzoite cysts in tissues such as the brain and eyes. These cysts can rupture, particularly in immunocompromised hosts, releasing active parasites and triggering recrudescence. Efforts to experimentally induce and study bradyzoite cyst recrudescence have been hindered by the limited capacity of cell culture adapted strains to form tissue cysts in vivo. T. gondii employs diverse strategies to persist within host cells, including manipulation of host metabolism and immune responses, and these strategies may vary by host cell type. Here, we profiled epigenomic and transcriptomic features associated with differential parasite survival in distinct cell types. Using an ex vivo model of the Type II ME49 strain unadapted to fibroblast culture, we compared parasite survival and epigenetic profiles in neonatal mouse astrocytes (AST) and human foreskin fibroblasts (HFF). Comparative analyses revealed marked divergence in parasite population dynamics, accompanied by reduced H3K4me3 enrichment at promoter regions in parasites grown in HFF. This epigenetic shift correlated with transcriptomic changes in genes linked to cell cycle progression, growth, and development, including a subset of AP2 transcription factors, underscoring the influence of host cell type on parasite biology.

Indexed as

Epigenesis, GeneticHost-Parasite InteractionsToxoplasmaToxoplasmosisAnimalsAstrocytesFibroblastsHistonesHumansMaleMiceTranscriptomeHistones

Identifiers

PMID42087241
PMCPMC13317167

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.