ReviewJournal of medical case reports2026
When history can mislead a physician: a challenging case report of idiopathic pulmonary hemosiderosis-A case report and review of the literature.
Review in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIdiopathic pulmonary hemosiderosis is a rare condition characterized by non-immune-mediated alveolar hemorrhage. Its nonspecific clinical and radiological features make diagnosis particularly challenging. Idiopathic pulmonary hemosiderosis typically presents in older children with a classic triad of hemoptysis, chest X-ray abnormalities, and iron deficiency anemia. In contrast, preschool-aged children may show subtle signs such as respiratory distress, persistent cough, and pallor, which can mimic respiratory infections and lead to severe anemia. Prompt recognition is critical, as iron deposition in the alveoli adversely affects prognosis. Delayed diagnosis may result in pulmonary fibrosis, respiratory failure, or the need for lung transplantation. CASE PRESENTATION: We report the case of a 3-year-old Asian girl with no significant medical history who presented with respiratory distress and severe anemia. She was initially treated as pneumonia with nutritional iron deficiency anemia, received a blood transfusion, and was discharged on iron and folic acid supplements; 2 weeks later, she returned with worsening respiratory distress, pallor, and hypoactivity. Workup revealed severe microcytic hypochromic anemia, elevated inflammatory markers, and bilateral heterogeneous opacities on chest X-ray. Diffuse alveolar hemorrhage was suspected and confirmed by bronchoscopy after exclusion of rheumatological diseases. Idiopathic pulmonary hemosiderosis was considered, and she was started on pulse methylprednisolone for 3 days, then weaned to maintenance prednisolone doses. Empirical antibiotics were discontinued after negative infectious studies. She showed significant clinical and radiological improvement within days, and at 2-month follow-up her hemoglobin was 11.2 g/dL.
conclusionThis case highlights the risk of misdiagnosing rare but serious conditions such as idiopathic pulmonary hemosiderosis. Early recognition and timely treatment are essential to improve outcomes and prevent long-term complications.
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