Evidence map›Paper›PMID 42087220›Full record

ArticleJournal of cardiothoracic surgery2026

Myectomy with secondary chordal resection in hypertrophic obstructive cardiomyopathy: the mid-term outcomes.

Zhuheng Wu, Zedong He, Lin Xie, Songbo Zhang, Hong Qian, Yajiao Li, Yanlin Yang, Changping Gan, Ke Lin

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Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Zhuheng Wu *Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Zedong He *Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Lin Xie *Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Songbo ZhangDepartment of Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.
Hong QianDepartment of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Yajiao LiDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Yanlin YangDepartment of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Changping GanDepartment of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Ke LinDepartment of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. linkehuaxi@wchscu.cn.

Funding

Natural Science Foundation of Sichuan Province 24NSFSC0233
6 · The paper itself

Abstract

backgroundIt is not clear whether septal myectomy with secondary chordal resection (SM-SCR) can achieve similar postoperative outcomes among hypertrophic obstructive cardiomyopathy (HOCM) patients exhibiting different severity of septal hypertrophy.

methodsThis was a single-center retrospective cohort study with a nested case-control study. HOCM patients received SM-SCR between 2014 and 2023 were retrospectively included and were grouped based on their septal thickness. The main outcome was the relief of the left ventricular outflow tract (LVOT) obstruction. Besides, predictors for recurrent mitral regurgitation (MR) were also explored.

resultsA total of 88 patients were included, with 63 in the significant hypertrophy group (SH group) and 25 in the mild hypertrophy group (MH group). The overall median follow-up time was 54.0 (33.0-79.0) months. Before adjusting the covariates, The LVOT gradients at the last follow-up were similar between groups [SH group vs. MH group: 10.0 (6.0-14.0) mmHg vs. 8.0 (6.0-11.5) mmHg, P = 0.556], while the interventricular septum (IVS) was thicker for the SH group [15.0 (12.0-17.0) mm vs. 13.0 (11.0-14.0) mm, P = 0.016]. In the fully adjusted model, both the LVOT gradients and the IVS thickness were comparable (P = 0.606 and 0.520 respectively). The risk of recurrent MR was similar between groups (7.9% vs. 8.0%, log-rank P = 0.879), while no predictors for recurrent MR were identified.

conclusionAccording to our single-center data, the mid-term outcomes after SM-SCR were comparable for HOCM patients with different severity of septal hypertrophy. However, further investigations with larger sample sizes and longer follow-up durations are needed.

trial registrationThe study was approved by the Institutional Review Board [2023(2408)], and patients' consents were waived due to the retrospective nature of the study.

Indexed as

Cardiomyopathy, HypertrophicChordae TendineaeHeart SeptumSeptal MyectomyCase-Control StudiesEchocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedMitral Valve InsufficiencyRetrospective StudiesTreatment OutcomeVentricular Outflow ObstructionVentricular Outflow Obstruction, LeftMitral regurgitationObstructive hypertrophic cardiomyopathySecondary chordal resectionSeptal myectomy

Identifiers

PMID42087220
PMCPMC13330400

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.