Evidence map›Paper›PMID 42087114›Full record

ArticleBMC psychiatry2026

Exploring client and clinician experiences of cognitive behavioural therapy for depersonalisation-derealisation disorder (CBT-f-DDD).

Cheuk Lon Malcolm Wong, Elaine C M Hunter, Toby Newson, Nicola Dalrymple, Joe Perkins, Nicola Morant

Abstract read
In one paragraph

Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cheuk Lon Malcolm WongDivision of Psychiatry, University College London, London, UK. malcolm.wong1@nhs.net.
Elaine C M HunterDivision of Psychiatry, University College London, London, UK.
Toby NewsonDepartment of Psychology, Royal Holloway University of London, Egham, UK.
Nicola DalrympleDivision of Psychiatry, University College London, London, UK.
Joe PerkinsUnreal Charity, Bristol, UK.
Nicola MorantDivision of Psychiatry, University College London, London, UK.

Funding

National Institute for Health Research PB-PG-NIHR202201
6 · The paper itself

Abstract

backgroundDepersonalisation-derealisation disorder (DDD) is an under-recognised condition, involving a sense of detachment from one's internal processes and environment. Cognitive behavioural therapy for DDD (CBT-f-DDD) has shown promising quantitative outcomes in previous research. However, there is a lack of research examining the inner workings of CBT-f-DDD and how the treatment is experienced. This qualitative study explored the experiences and perspectives of clients who received CBT-f-DDD, and the clinicians who delivered this, to better understand acceptability, feasibility of applying CBT-f-DDD more widely in the NHS, and therapeutic processes that potentially contributed to outcomes.

methodsThe study was embedded within a CBT-f-DDD feasibility randomised controlled trial in the UK. Participants consisted of clients who completed therapy and clinicians recruited from the treatment arm of the trial. Semi-structured interviews were conducted with seven clients and seven therapists after therapy. Data were analysed using codebook thematic analysis.

resultsFindings clustered into four broad domains are presented: "reception of therapy", "possible therapeutic processes as drivers for change", "improving the therapy", and "treatment implementation in the NHS". Clients expressed appreciation for being offered the opportunity to engage in CBT-f-DDD. CBT was considered an appropriate approach to treating DDD and treatment completers saw various therapeutic benefits, including a decrease in symptoms, improved relationship with DDD and higher confidence in managing dissociation. A few clients shared that interventions were not sufficiently targeted. Challenges of accommodating comorbid mental health difficulties within the CBT-f-DDD model were described by a few clinicians. Clinicians viewed CBT-f-DDD as feasible for delivery in the NHS. However, establishing effective treatment pathways and facilitating appropriate training and supervision for clinicians were considered important prerequisites. Building a strong therapeutic rapport, constructing a shared understanding of DDD and the reframing of thoughts were perceived by clients and clinicians to be crucial components connected with positive outcomes.

conclusionsThe acceptability of CBT-f-DDD to both clients who completed therapy and clinicians was somewhat supported. The treatment was also deemed conditionally feasible for wider implementation. It is recommended that CBT-f-DDD be further refined in line with client needs, perceived mechanisms of change, professional training needs, and organisational factors.

trial registrationThis study was embedded within a trial registered with the ISRCTN (registration number: ISRCTN97686121; registration date: 5th January 2023; https://doi.org/10.1186/ISRCTN97686121 ).

Indexed as

Attitude of Health PersonnelCognitive Behavioral TherapyDepersonalizationPatient SatisfactionAdultFeasibility StudiesFemaleHumansMaleMiddle AgedQualitative ResearchRandomized Controlled Trials as TopicTreatment OutcomeAcceptabilityCognitive behavioural therapyDepersonalisationDerealisationDissociationFeasibilityQualitativeTreatment experience

Identifiers

PMID42087114
PMCPMC13312645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.