Evidence map›Paper›PMID 42087061›Full record

ArticleRenal failure2026

PCSK6 is a novel regulator of venous smooth muscle cell function in arteriovenous fistula remodeling.

Xiangjiang Guo, Ruzhou Cao, Tianchen Wang, Lan Zhang, Yinan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiangjiang GuoDepartment of Vascular Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ruzhou CaoDepartment of Vascular Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tianchen WangDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, USA.
Lan ZhangDepartment of Vascular Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yinan LiDepartment of Vascular Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The arteriovenous fistula (AVF), the preferred vascular access for hemodialysis, is limited by neointimal hyperplasia. Although proprotein convertase subtilisin/kexin type 6 (PCSK6) is involved in vascular smooth muscle cell (VSMC) activation, its role in AVF stenosis is unclear. PCSK6 expression was significantly upregulated in VSMCs of human and murine stenotic AVFs and correlated with the severity of neointimal hyperplasia.

Indexed as

Arteriovenous Shunt, SurgicalMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaProprotein ConvertasesSubtilisinsVascular RemodelingAnimalsCell MovementCell ProliferationExtracellular MatrixHumansHyperplasiaMaleMiceMice, KnockoutPCSK6 protein, humanPcsk6 protein, mouseProprotein ConvertasesSerine EndopeptidasesSTAT1 protein, humanSTAT1 Transcription FactorSubtilisinsArteriovenous fistulaPCSK6STAT1vascular remodeling

Identifiers

PMID42087061
PMCPMC13148085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.