Evidence map›Paper›PMID 42087039›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

The design and synthesis of cysteine protease inhibitors containing isoxazole bearing warheads against Leishmania donovani.

Gowsia Akhter, Mirza A Beg, Sayeed Ur Rehman, Angamuthu Selvapandiyan, Kalicharan Sharma, Bharti Dhawan, Md Sarfaraz, Mohammad Sarwar Alam, Mushtaq A Tantray, Hinna Hamid

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Gowsia AkhterDepartment of Chemistry, School of Chemical and Life Sciences, Jamia Hamdard, 110062, New Delhi, India.
Mirza A BegDepartment of Molecular Medicine, School of Interdisciplinary Sciences and Technology, Jamia Hamdard, New Delhi, India, 110062.
Sayeed Ur RehmanDepartment of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, 110062, New Delhi, India.
Angamuthu SelvapandiyanDepartment of Molecular Medicine, School of Interdisciplinary Sciences and Technology, Jamia Hamdard, New Delhi, India, 110062.
Kalicharan SharmaISF College of Pharmacy, Moga, Punjab, 142001, India.
Bharti DhawanDepartment of Chemistry, School of Chemical and Life Sciences, Jamia Hamdard, 110062, New Delhi, India.
Md SarfarazDepartment of Molecular Medicine, School of Interdisciplinary Sciences and Technology, Jamia Hamdard, New Delhi, India, 110062.
Mohammad Sarwar AlamDepartment of Chemistry, School of Chemical and Life Sciences, Jamia Hamdard, 110062, New Delhi, India. msalam@jamiahamdard.ac.in.
Mushtaq A TantrayDepartment of Chemistry, Govt. Degree College Baramulla, Khawaja Bagh, J&K 193101, India. mushisjchem@gmail.com.
Hinna HamidDepartment of Chemistry, School of Chemical and Life Sciences, Jamia Hamdard, 110062, New Delhi, India. hhamid@jamiahamdard.ac.in.

Funding

Indian Council of Medical Research 45/35/2020/BIO/BMSSERB, DST TARE/2019/000110
6 · The paper itself

Abstract

Cysteine proteases are critical drug targets for Trypanosomatids, crucial for the host cell invasion, survival and establishing infection. The current therapeutic regimen for leishmaniasis is inadequate, necessitating the search for safer anti-leishmanial agents. A fourteen-member library of new isoxazole derivatives was synthesised using a 1, 3-dipolar cycloaddition approach and then evaluated for antileishmanial activity. Ligands PB, PM and PE were found most effective against intramacrophage amastigotes of Leishmania donovani with EC

Indexed as

Antiprotozoal AgentsCysteine Proteinase InhibitorsDrug DesignIsoxazolesLeishmania donovaniAnimalsHumansMolecular Docking SimulationStructure-Activity RelationshipTHP-1 CellsAntiprotozoal AgentsCysteine Proteinase InhibitorsIsoxazolesAntileishmanialCysteine protease inhibitorsIn-silico docking studiesIsoxazoleLeishmania donovaniSynthesis

Identifiers

PMID42087039

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.