Evidence map›Paper›PMID 42087019›Full record

ReviewAAPS PharmSciTech2026

Advancement in Sodium Alginate-Based Drug Delivery Systems: Applications and Future Prospects.

Anjali Kumari, Bonthu Varunteja, Satyajit Mohanty, Anjali Mishra, Nayan Gupta, Tuhin Mukherjee, Bhawna Sharma, Nikita Nayak, Anwesha Sahu, Ashok Pattnaik and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anjali Kumari *Team Photonics & Metabolics, Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.
Bonthu Varunteja *Team Photonics & Metabolics, Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.
Satyajit Mohanty *Team Photonics & Metabolics, Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India. satyajitmohanty922@gmail.com.ORCID http://orcid.org/0000-0001-6665-3432
Anjali MishraDepartment of Pharmacy, Sarala Birla University, Ranchi, Jharkhand, 835103, India.
Nayan GuptaTeam Photonics & Metabolics, Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.
Tuhin MukherjeeTeam Photonics & Metabolics, Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India. tuhin.bzs@gmail.com.ORCID http://orcid.org/0000-0002-8114-9952
Bhawna SharmaDepartment of Pharmaceutics, Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad, Uttar Pradesh, 201204, India.
Nikita NayakTeam Photonics & Metabolics, Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.
Anwesha SahuDivision of Pharmacology, Faculty of Medical Science and Research, Sai Nath University, Ranchi, Jharkhand, 835219, India.
Ashok PattnaikTeam Photonics & Metabolics, Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India. ashokp29@yahoo.com.ORCID http://orcid.org/0000-0003-2931-9042
Pranav Kumar PrabhakarDepartment of Biotechnology, School of Engineering and Technology, Nagaland University, Meriema, Kohima, Nagaland, 797004, India.
Uttam Kumar MishraDepartment of Chemistry, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For over five decades, sodium alginate (SA) has been widely employed in pharmaceutical formulations due to its environmentally friendly, biodegradable, and biocompatible nature. Primarily sourced from brown seaweed, this natural polymer plays a crucial role in enhancing drug delivery control. It serves as a versatile excipient in numerous dosage forms such as capsules, tablets, liposomes, and microspheres. SA ionotropic gelation with calcium ions allows drug and enzyme encapsulation for controlled release. Structurally, SA consists of α-L-guluronic acid and β-D-mannuronic acid monomers linked via glycosidic bonds, enabling the formation of strong, porous hydrogels capable of carrying bioactive substances. These hydrogels have been extensively utilized in ocular and oral drug delivery systems for prolonged therapeutic effect. This review highlights the structural and physicochemical characteristics of SA, its pharmaceutical and biomedical applications, food industry relevance, and recent innovations, while also discussing its potential as a multifunctional material for future drug delivery systems.

Indexed as

AlginatesDrug Delivery SystemsChemistry, PharmaceuticalDelayed-Action PreparationsDrug CarriersExcipientsGlucuronic AcidHexuronic AcidsHumansHydrogelsMicrospheresPolymersAlginatesDelayed-Action PreparationsDrug CarriersExcipientsGlucuronic AcidHexuronic AcidsHydrogelsPolymersBiomedical ApplicationsDrug DeliveryPharmaceutical ApplicationSodium Alginate

Identifiers

PMID42087019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.