Evidence map›Paper›PMID 42086826›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Kinetic modelling of [⁶⁸Ga]Ga-FAPI-46 PET in pancreaticobiliary lesions: distinguishing cancer from pancreatitis.

Ted Nilsson, Pawel Rasinski, Ernesto Sparrelid, Antonios Tzortzakakis, Thuy A Tran, Örjan Smedby, Rimma Axelsson, Mark Lubberink, Maria Holstensson

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05172310 (PET Imaging of Tumors in Pancreas, Bile Ducts, Stomach and Ovaries by a Novel Tracer, 68Ga-FAPI-46 = Fibroblast Activation Protein Inhibitor), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05172310 phase1recruitingnot on this map

PET Imaging of Tumors in Pancreas, Bile Ducts, Stomach and Ovaries by a Novel Tracer, 68Ga-FAPI-46 = Fibroblast Activation Protein Inhibitor

TypeinterventionalSponsorKarolinska University HospitalRan2021 to 2029Enrolled410ConditionsPancreatic Neoplasms, Stomach Neoplasms, Bile Duct Neoplasms, Epithelial Ovarian CancerArms68Ga-FAPI-46, PET/CT
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ted NilssonDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. ted.nilsson@regionstockholm.se.ORCID 0009-0008-0147-0676
Pawel RasinskiDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Ernesto SparrelidDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Antonios TzortzakakisDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Thuy A TranTheranostics Trial Center, Karolinska University Hospital, Huddinge, Sweden.
Örjan SmedbyDepartment of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Huddinge, Sweden.
Rimma AxelssonDepartment of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Huddinge, Sweden.
Mark LubberinkMolecular Imaging and medical physics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Maria HolstenssonDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFibroblast activation protein (FAP)-targeted PET using [⁶⁸Ga]Ga-FAPI-46 visualizes fibroblasts abundant in pancreatic cancer (PC) but also present in pancreatitis, complicating interpretation of static images. Dynamic imaging and kinetic modeling may provide additional insight, but their diagnostic value remains unclear. This study evaluated whether kinetic parameters from dynamic [⁶⁸Ga]Ga-FAPI-46 PET can differentiate PC from pancreatitis and their relationship with standardized uptake value (SUV) and tumor-to-blood ratio (TBR).

methodsSixty-one patients with suspected pancreaticobiliary cancer underwent a 45-min dynamic [⁶⁸Ga]Ga-FAPI-46 PET scan, followed by static scans at 60 and 180 min. Time-activity curves were generated for 51 malignant and 53 benign lesions. Compartment models and Logan analysis yielded kinetic parameters (K

resultsReversible models best described the tracer kinetics. V

conclusionsKinetic parameters showed strong correlations with simplified methods and similar ability to differentiate PC from pancreatitis. SUV and TBR measures thus represent practical alternatives to kinetic modelling for lesion characterization. CLINICALTRIALS: gov ID: NCT05172310.

Indexed as

Models, BiologicalPancreatic NeoplasmsPancreatitisPositron-Emission TomographyAdultAgedAged, 80 and overDiagnosis, DifferentialEndopeptidasesFemaleFibroblast Activation Protein AlphaGallium RadioisotopesHumansKineticsMaleMiddle Aged68Ga-FAPIEndopeptidasesFibroblast Activation Protein AlphaGallium RadioisotopesQuinolines[⁶⁸Ga]Ga-FAPI-46Dynamic PETKinetic modellingPancreatic cancer

Identifiers

PMID42086826
PMCPMC13314683

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.