Evidence map›Paper›PMID 42086727›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Understanding perspectives of safety-net NICU neonatologists disclosing genomic sequencing results: a mixed methods approach.

Sonia Hills, Meghan Werner, Jessica Douglas, Alissa M D'Gama, Monica H Wojcik, Vanessa Young, VIGOR Network, Timothy W Yu, Pankaj B Agrawal, Margaret G Parker

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05205356 (VIGOR), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05205356 active not recruitingnot on this map

VIGOR: Virtual Genome Center for Infant Health

TypeobservationalSponsorBoston Children's HospitalRan2022 to 2027Enrolled631ConditionsGenetics Disease, Genetics/Birth Defects, Genetic Predisposition to Disease
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sonia HillsDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5302-3236
Meghan WernerDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Jessica DouglasDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Alissa M D'GamaDivision of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2482-5328
Monica H WojcikDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8162-5031
Vanessa YoungDivision of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2258-4433
VIGOR Network
Timothy W YuDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2988-7701
Pankaj B AgrawalDivision of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine and Holtz Children's Hospital, Jackson Health System, Miami, FL, USA.
Margaret G ParkerDepartment of Pediatrics, UMass Chan Medical School, Worcester, MA, USA. Margaret.Parker@umassmemorial.org.ORCID http://orcid.org/0000-0001-6338-3350

Funding

VIGOR: Virtual Genome Center for Infant HealthR01HG011798 · NHGRI · BOSTON CHILDREN'S HOSPITAL · PI AGRAWAL, PANKAJ B, PARKER, MARGARET GRAHAM KEMPER · 2021 to 2025
$5.1M
The Burden of Genetic Disorders in Infant MortalityK23HD102589 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI WOJCIK, MONICA HSIUNG · 2020 to 2024
$840k
NHGRI NIH HHS R01 HG011798NICHD NIH HHS K23 HD102589
6 · The paper itself

Abstract

objectiveExamine neonatologists' perspectives on disclosing rapid genomic sequencing (rGS) results, including the barriers and facilitators they perceive. STUDY

designNeonatologists from 10 NICUs participating in the Virtual Genome Center (VIGOR) study were surveyed after each rGS disclosure and interviewed regarding their experience after 2 or more disclosures. Quantitative results were compared by result type, and qualitative results were iteratively coded for themes.

results93% of neonatologists felt comfortable disclosing rGS results regardless of result type. Neonatologists utilized multiple resources to prepare for disclosures, including the VIGOR Clinical Interpretive Report, medical literature, and local genetics experts. They preferred to have a geneticist present during disclosure when possible. Neonatologists were motivated to participate in disclosures to help families and leverage existing trust.

conclusionNeonatologists are important to the rGS disclosure experience, but a joint effort with genetics experts may be the ideal model to successfully expand access. TRIAL REGISTRATION NUMBER: NCT05205356/clinicaltrials.gov .

Identifiers

PMID42086727

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.