Evidence map›Paper›PMID 42086673›Full record

ArticleBritish journal of cancer2026

Targeting NUDT21-mediated alternative polyadenylation of oncogenes ameliorates colorectal cancer malignancy and metastasis.

Shih-Chieh Lin, Ya-Chuan Tsai, Jui-Lin Wang, Hsian-Jean Chin, Ching-Chin Tsai, Shin-Chih Lin, Yi-Syuan Lin, Bo-Wen Lin, Shaw-Jenq Tsai

Abstract read
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In one paragraph

Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Pharmaceuticals (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shih-Chieh LinInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC. Jaylin@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-9967-5037
Ya-Chuan TsaiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Jui-Lin WangNational Laboratory Animal Center, National Applied Research Laboratories, Tainan, Taiwan, ROC.
Hsian-Jean ChinNational Laboratory Animal Center, National Applied Research Laboratories, Tainan, Taiwan, ROC.
Ching-Chin TsaiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Shin-Chih LinInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Yi-Syuan LinInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.ORCID http://orcid.org/0000-0001-6574-6952
Bo-Wen LinDepartment of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Shaw-Jenq TsaiDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC. seantsai@ccu.edu.tw.

Funding

National Health Research Institutes (NHRI) NHRI-EX112-11220BINational Health Research Institutes (NHRI) NHRI-EX113-11220BI
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is a disease leading cause of death worldwide. Lacking molecular markers for early detection and suitable candidates for targeted therapies are two main reasons for causing CRC malignancy.

objectivesExploring the role of NUDT21 in colorectal cancer metastasis.

methodsA systematic bioinformatic analysis identified key genes involved in colorectal cancer, which were subsequently validated through loss-of-function and gain-of-function experiments conducted both in vitro and in vivo.

resultsOverexpression of nucleoside diphosphate linked moiety X hydrolases-type motif 21 (NUDT21), a critical factor that regulates alternative polyadenylation, is observed in malignant polyps and in human and mouse CRC. Survival analysis reveals that high level of NUDT21 is associated with poor prognosis. NUDT21 knockdown not only inhibits cell growth but also reduces malignancy traits like anchorage-independent growth and cancer stemness. RNA-seq and RIP-seq results show NUDT21 preferentially binds to the proximal alternative polyadenylation site of numerous oncogenes to promote their expression and thus drive the progression of CRC. Treatment with re-purposing drugs targeting NUDT21 exhibit therapeutic potential in cell culture, organoid, orthotopic, and patient-derived xenografted CRC models.

conclusionsThese findings demonstrate that NUDT21 is a critical regulator of colon cancer progression and a promising therapeutic target for CRC.

Indexed as

Cleavage And Polyadenylation Specificity FactorColorectal NeoplasmsOncogenesPolyadenylationAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMiceNeoplasm MetastasisCleavage And Polyadenylation Specificity FactorNudt21 protein, human

Identifiers

PMID42086673
PMCPMC13427831

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.