Evidence map›Paper›PMID 42086670›Full record

ArticleBritish journal of cancer2026

Blocking mitochondrial leucine transamination enhances T-cell activation and improves T-cell immunity against OVA-producing EL4 lymphoma.

Christie M Adam, Tanner J Wetzel, Sheila C Erfan, Leighton M Wheeler, Emily E Baer, Lindsey P Croll, Alexander M Martin, Taha Z Khan, Max L Swain, Michael P Boyer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christie M Adam *Department of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Tanner J Wetzel *Department of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Sheila C ErfanDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Leighton M WheelerUF Shands Hospital, University of Florida, Gainesville, FL, USA.
Emily E BaerDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Lindsey P CrollDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Alexander M MartinFlushing Hospital Medical Center, New York, NY, USA.
Taha Z KhanDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Max L SwainDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Michael P BoyerDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Elitsa A AnanievaDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA. elitsa.ananieva-stoyanova@dmu.edu.ORCID http://orcid.org/0000-0003-3828-2093

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT-cell metabolism is targeted by cancer cells in an attempt to escape immune surveillance. The mitochondrial branched-chain aminotransferase, BCATm, is overexpressed in cancer, yet its role in T-cell immunity is suggested but understudied.

methodsC57BL/6 mice with T-cell specific-single BCATm deficiency were used to determine the impact of BCATm on T-cell function in vitro and in vivo using the murine EL4-OVA lymphoma. The studies were complemented by a transcriptomic correlation analysis of BCATm in human T cells and by using siRNA to knock-down BCATm in Jurkat T cells.

resultsThe loss of BCATm from CD4

conclusionsBCATm is an immunosuppressive enzyme that may weaken T-cell performance in the lymphoma microenvironment.

Indexed as

Lymphocyte ActivationLymphomaMitochondriaT-LymphocytesTransaminasesAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansJurkat CellsMiceMice, Inbred C57BLMice, KnockoutTransaminases

Identifiers

PMID42086670
PMCPMC13372810

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.