ArticleScientific reports2026
Joint risk factor within target range and hazard of premature mortality in people with obesity.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals with obesity are at higher risk for premature mortality compared to the general population. However, whether achieving multiple modifiable risk factors within target ranges is associated with attenuated excess mortality risk in obesity remains unclear. We included 83,505 participants with obesity and 143,198 individuals without obesity from the UK Biobank, all free of baseline cancer and cardiovascular disease (CVD). The main exposure was the number of risk factors within target range, including glycated hemoglobin < 48 mmol/mol, low-density lipoprotein cholesterol (LDL-C) < 2.5 mmol/L, absence of albuminuria, non-current smoker, and systolic blood pressure < 140 mmHg and diastolic blood pressure < 90 mmHg. Cox proportional hazards models adjusted for age, sex, ethnicity, education, socioeconomic status, alcohol intake, healthy diet score, and physical activity were used to evaluate the association between the degree of risk factor within target range and risks of all-cause, cancer, CVD, and other-cause premature mortality. Fine-Gray competing risk models were performed as sensitivity analyses. The proportional hazards assumption was verified using Schoenfeld residuals. Among individuals with obesity, each additional risk factor within target range was associated with 17%, 11%, 28%, and 16% lower risks of all-cause, cancer, CVD, and other-cause premature mortality, respectively. Participants with obesity who achieved all five risk factors had 47%, 38%, 63%, and 47% lower risks compared to those meeting ≤ 2 factors. However, as the number of risk factors within target range increased, the excess mortality risks progressively diminished. Individuals with obesity meeting all 5 factors showed risks approaching those of individuals without obesity, particularly for CVD and other-cause mortality. Achieving multiple modifiable risk factors within target ranges was associated with substantially lower premature mortality risk among individuals with obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.