Evidence map›Paper›PMID 42086566›Full record

ArticleNature communications2026

Clusia genomes shed light on the evolution and diversity of crassulacean acid metabolism physiotypes.

Hannes M Kramml, Johannes B Herpell, Clara Priemer, Zoe Wessely, Florian Schindler, Andreas Berger, Maximilian Kellner, Stefan Plott, Ágnes Dohovits, Tamara Schmidt and 20 more

Abstract readComparative Study
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Hannes M Kramml *Molecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.ORCID 0000-0003-2065-4565
Johannes B Herpell *Molecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.ORCID 0000-0002-9183-7142
Clara PriemerMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.ORCID 0009-0004-9636-5799
Zoe WesselyMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.ORCID 0009-0006-0855-3998
Florian SchindlerMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.ORCID 0000-0001-5248-8739
Andreas BergerDepartment of Botany, Natural History Museum Vienna, Vienna, Austria.ORCID 0000-0003-3902-3827
Maximilian KellnerMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
Stefan PlottMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.ORCID 0000-0002-9135-3519
Ágnes DohovitsMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
Tamara SchmidtMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
Peter KerpanDepartment of Botany and Biodiversity Research, University of Vienna, Vienna, Austria.ORCID 0000-0001-9742-5432
Leila Afjehi-SadatMass Spectrometry Unit, Research Support Facilities, University of Vienna, Vienna, Austria.ORCID 0000-0001-6355-8077
Palak ChaturvediMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.ORCID 0000-0002-5856-0348
Arindam GhatakMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.ORCID 0000-0003-4706-9841
Martin BrennerMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
Iro PieridesMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
Lena FragnerMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
Eva M TemschDepartment of Botany and Biodiversity Research, University of Vienna, Vienna, Austria.ORCID 0000-0002-0805-9096
Fabio TrevisanMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
Menriti IbrahimMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
Felix FromwaldMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
Anke BellaireDepartment of Botany and Biodiversity Research, University of Vienna, Vienna, Austria.
Oleg SimakovDepartment of Neuroscience and Developmental Biology, University of Vienna, Vienna, Austria.ORCID 0000-0002-3585-4511
Werner HuberDepartment of Botany and Biodiversity Research, University of Vienna, Vienna, Austria.
Ulrich LüttgeInstitute of Botany, Technical University of Darmstadt, Darmstadt, Germany.
Ovidiu PaunDepartment of Botany and Biodiversity Research, University of Vienna, Vienna, Austria.ORCID 0000-0002-8295-4937
Susann WickeInstitute for Evolution and Biodiversity, University of Muenster, Muenster, Germany.ORCID 0000-0001-5785-9500
Hanna Weiss-SchneeweissDepartment of Botany and Biodiversity Research, University of Vienna, Vienna, Austria.ORCID 0000-0002-9530-6808
Gert BachmannMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria.
Wolfram WeckwerthMolecular Systems Biology (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria. wolfram.weckwerth@univie.ac.at.ORCID 0000-0002-9719-6358

Funding

Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) DOC111
6 · The paper itself

Abstract

More than 200 years ago, Alexander von Humboldt described a tree of the genus Clusia for its ability to perform crassulacean acid metabolism (CAM). This drought-adaptive metabolism allows plants to maintain photosynthesis under water limitation by temporally separating CO₂ uptake and fixation. The diversity of CAM physiotypes has fueled a debate about evolutionary constraints and the feasibility of engineering CAM into C₃ crops. The genus Clusia displays an exceptional diversity of photosynthetic physiotypes, yet genome sequences and genomic mechanisms generating this diversity remain unresolved. Here, we sequence and compare the genomes of three Clusia species spanning weak, inducible, and strong CAM. We show that polyploidization followed by transposon-mediated genic diploidization could have shaped CAM-related gene families, particularly those controlling phosphoenol-pyruvate recycling via phosphorolytic leaf starch metabolism. Our results indicate that whole-genome duplication coupled to diploidization might have driven diversification of CAM physiotypes in Clusia, providing a genomic framework for understanding CAM diversity and evolution.

Indexed as

Biological EvolutionClusiaCrassulacean Acid MetabolismGenome, PlantPolyploidyChromosomes, PlantGenetic Variation

Identifiers

PMID42086566
PMCPMC13144421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.