Evidence map›Paper›PMID 42086557›Full record

ArticleNature communications2026

Construction of quaternary stereocenters via Ru-catalyzed asymmetric ring-closing metathesis.

Shaofeng Li, Qingjing Yang, Rongjun Hu, Yichuan Zheng, Xiaojing Gao, Junjie Cao, Jianchun Wang, Bo Chen, Chen Xu, Xiangyou Xing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Shaofeng Li *Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China.
Qingjing Yang *Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0001-8968-2009
Rongjun HuShenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China.
Yichuan ZhengShenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China.
Xiaojing GaoShenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China.
Junjie CaoShenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China.
Jianchun WangShenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0002-3998-8699
Bo ChenShenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China. chenb@sustech.edu.cn.ORCID http://orcid.org/0000-0003-3296-0922
Chen XuShenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China. xuc@sustech.edu.cn.ORCID http://orcid.org/0000-0002-3222-459X
Xiangyou XingShenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China. xingxy@sustech.edu.cn.ORCID http://orcid.org/0000-0002-2456-0825

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asymmetric olefin metathesis, which forms C = C double bonds while simultaneously inducing chirality in molecules, is highly valuable in chemical synthesis. The investigation of strategies for the creation of quaternary stereocenters has mostly focused on Mo-based catalytic systems, whilst the utilization of user-friendly Ru-catalysts has been rarely reported. Here, by precisely synthesizing stereogenic-at-Ru catalysts via controllable C-H activation, we accomplish highly efficient asymmetric ring-closing metathesis (ARCM) for the production of chiral heterocyclic compounds with quaternary stereocenters. These Ru-catalysts facilitate the ARCM of trienes with distinct olefins for the synthesis of six-membered ethers and amines, as well as ARCM of trienes with all-terminal olefins to yield five- and six-membered ethers. Mechanistic investigations involving the initiation of the ARCM reaction by ring-opening metathesis of a "single-addition" cyclopropene derivative provide strong evidence for the interconversion between the essential exo and endo Ru-alkylidenes, and DFT calculations help to further substantiate the favored pathway and the stereo-controlling mechanism. This study provides an attractive approach for the design and production of chiral Grubbs catalysts, thereby promoting a variety of asymmetric olefin metathesis processes.

Identifiers

PMID42086557
PMCPMC13346952

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