Evidence map›Paper›PMID 42086546›Full record

ArticleNature communications2026

NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer.

Pavla Ticha, Jason J Northey, Radhika Narain, Shivang Sharma, Johnathon N Lakins, Hugo Gonzalez, Kelly Kersten, Alastair J Ironside, Allison P Drain, Martin Zidek and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Pavla Ticha *Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA.
Jason J Northey *Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3115-2560
Radhika Narain *Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA.
Shivang SharmaDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Johnathon N LakinsDepartment of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA.
Hugo GonzalezCentro BASAL Ciencia & Vida FB210008, Fundación Ciencia & Vida, Santiago, Chile.
Kelly KerstenDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7615-2594
Alastair J IronsideDepartment of Pathology, Western General Hospital, NHS Lothian, Edinburgh, UK.
Allison P DrainDepartment of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0841-9415
Martin ZidekDepartment of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA.
Kelvin K TsaiLaboratory of Advanced Molecular Therapeutics, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yunn-Yi ChenDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Eugene ShenderovDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9886-8542
Valerie M WeaverDepartment of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA, USA. Valerie.weaver@ucsf.edu.ORCID http://orcid.org/0000-0003-4786-6752

Funding

Tissue mechanics reprograms the tissue to malignancy and metastasisR35CA242447 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VALERIE MARIE WEAVER · 2020 to 2026
$6.6M
Illumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583k
Breast Cancer Research Foundation (BCRF) A132292Nancy Lurie Marks Family Foundation (NLM Family Foundation) 20-036-EDVNCI NIH HHS R35 CA242447NIH HHS S10 OD028511U.S. Department of Defense (United States Department of Defense) W81XWH-16-PCRP-CCRSAU.S. Department of Defense (United States Department of Defense) W81XWH-19-1-0511U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1S10OD028511-01U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35 CA242447-01A1
6 · The paper itself

Abstract

Metastatic progression depends upon the ability of disseminated tumor cells to evade immune surveillance. Major Histocompatibility Complex (MHC)-mediated antigen presentation facilitates T cell-dependent eradication of metastatic tumor cells. Here, we show that nuclear corepressor 2 (NCOR2) is an epigenetic regulator of MHC class I molecule presentation on breast tumor cells. Patients with triple negative breast cancer (TNBC) that express high levels of NCOR2 also exhibit reduced metastasis-free survival and decreased MHC class I expression, and the metastatic lesions in patients with TNBC have high nuclear NCOR2 and reduced Cluster of Differentiation (CD)8

Indexed as

Breast NeoplasmsHistocompatibility Antigens Class INuclear Receptor Co-Repressor 2AnimalsApoptosisCD8-Positive T-LymphocytesCell Line, TumorDisease ProgressionEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHistone Deacetylase 3Histone DeacetylasesHumansMiceNeoplasm MetastasisHistocompatibility Antigens Class IHistone Deacetylase 3Histone DeacetylasesNCOR2 protein, humanNuclear Receptor Co-Repressor 2

Identifiers

PMID42086546
PMCPMC13351013

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.