Evidence map›Paper›PMID 42086502›Full record

ArticleACS synthetic biology2026

Systematic Evaluation of Different Ribonucleoprotein Complexes as Posttranscriptional Biosensors in Cell-Free TX-TL Systems.

Dudu Boyvat, Francesco Grassi, Lucia Cassella, Velia Siciliano

Abstract read
In one paragraph

Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dudu BoyvatIstituto Italiano di Tecnologia-IIT, Synthetic and Systems Biology lab for Biomedicine, Largo Barsanti e Matteucci 53, 80125 Naples, Italy.
Francesco GrassiIstituto Italiano di Tecnologia-IIT, Synthetic and Systems Biology lab for Biomedicine, Largo Barsanti e Matteucci 53, 80125 Naples, Italy.
Lucia CassellaIstituto Italiano di Tecnologia-IIT, Synthetic and Systems Biology lab for Biomedicine, Largo Barsanti e Matteucci 53, 80125 Naples, Italy.ORCID 0000-0001-5109-0550
Velia SicilianoIstituto Italiano di Tecnologia-IIT, Synthetic and Systems Biology lab for Biomedicine, Largo Barsanti e Matteucci 53, 80125 Naples, Italy.ORCID 0000-0001-7734-9153

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic biology has enabled the development of sophisticated cell-free biosensors capable of complex, sensitive signal detection with promising clinical and environmental applications due to their ease of use, fast readout development, portability, and built-in biosafety. Nevertheless, the potential of ribonucleoprotein (RNP) complexes as posttranscriptional biosensors in cell-free transcription-translation (TX-TL) systems remains largely unexplored. In this study, we test the performance of three different posttranscriptional circuits (RISC:

Indexed as

Biosensing TechniquesRibonucleoproteinsCell-Free SystemEscherichia coliGenes, ReporterMicroRNAsProtein BiosynthesisSynthetic BiologyTranscription, GeneticMicroRNAsRibonucleoproteins

Identifiers

PMID42086502
PMCPMC13185155

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.