Trial reportInternational journal of radiation oncology, biology, physics2026
Mature Outcomes of 61.2 Gy Concomitant Boost Thoracic Radiation Therapy in Limited-Stage Small Cell Lung Cancer: CALGB 30610 (Alliance)/RTOG 0538.
Trial report in International journal of radiation oncology, biology, physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
purposeWe report mature outcomes of patients with limited-stage small cell lung cancer randomly assigned to the 61.2 Gy concomitant boost (CB) thoracic radiation therapy (TRT) arm of Cancer and Leukemia Group B (CALGB) 30610/Radiation Therapy Oncology Group (RTOG) 0538. The CB arm was discontinued after planned interim analysis; however, the study provides the largest prospective data set using 61.2 Gy CB TRT. METHODS AND MATERIALS: Eligible patients had limited-stage small cell lung cancer with regional lymph node involvement and Eastern Cooperative Oncology Group performance status 0 to 2. TRT began with either the first or second (of 4 total) cycle of cisplatin-based chemotherapy. Three-dimensional conformal radiation therapy or intensity modulated radiation therapy planning was required. In the initial phase of the trial, patients were randomly assigned with a 1:1:1 allocation to 45 Gy twice daily, 70 Gy once daily, and 61.2 Gy CB TRT.
resultsNinety-three patients were assigned to receive 61.2 Gy CB TRT. After a median follow-up of 115 months for surviving patients, median overall survival and progression-free survival were 32.3 months (95% CI, 20.4-44.8 months) and 15.4 months (95% CI, 10.0-24.0 months), respectively. Five-year overall survival was 28.5% (95% CI, 20.6-39.6). Rates of grade 3 and 4 nonhematologic adverse events were 40.9% and 25%, including 16% dysphagia and 7% severe pulmonary toxicity.
conclusionsCB TRT outcomes appear similar to contemporaneous trials using 45 Gy twice-daily or high-dose once-daily TRT and compare favorably with prior phase 2 data. Improved outcomes highlight the impact of advances in staging and radiation therapy techniques, although additional factors may have contributed.
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