Evidence map›Paper›PMID 42086122›Full record

ArticleContemporary clinical trials2026

Conducting multicenter trials through the trial innovation network comprehensive consultation.

Daniel F Hanley, Karen Lane, Nichol McBee, Lindsay M Eyzaguirre, W Andrew Mould, Elizabeth Holthouse, Jessica F Baird, Jonathan D Casey, Consuelo H Wilkins, Salina P Waddy and 29 more

Abstract read
In one paragraph

Article in Contemporary clinical trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Daniel F HanleyDepartment of Neurology, BIOS Clinical Trial Coordinating Center, Trial Innovation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Johns Hopkins Institute for Clinical and Translational Research, Baltimore, MD, USA. Electronic address: dhanley@jhmi.edu.
Karen LaneDepartment of Neurology, BIOS Clinical Trial Coordinating Center, Trial Innovation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nichol McBeeDepartment of Neurology, BIOS Clinical Trial Coordinating Center, Trial Innovation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lindsay M EyzaguirreDepartment of Neurology, BIOS Clinical Trial Coordinating Center, Trial Innovation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
W Andrew MouldDepartment of Neurology, BIOS Clinical Trial Coordinating Center, Trial Innovation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elizabeth HolthouseDepartment of Neurology, BIOS Clinical Trial Coordinating Center, Trial Innovation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jessica F BairdDepartment of Neurology, BIOS Clinical Trial Coordinating Center, Trial Innovation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jonathan D CaseyVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Consuelo H WilkinsVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Internal Medicine, Meharry Medical College, Nashville, TN, USA.
Salina P WaddyNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Ken L WileyNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Sara HassaniNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Meghan HildrethDepartment of Neurology, BIOS Clinical Trial Coordinating Center, Trial Innovation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Angeline NanniDepartment of Neurology, BIOS Clinical Trial Coordinating Center, Trial Innovation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Terri L EdwardsVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Dixie D ThompsonUniversity of Utah Health, Salt Lake City, UT, USA; Utah Clinical & Translational Science Institute, Salt Lake City, UT, USA.
Mary StroudVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Emily SerdozVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Nan KennedyVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Sarah J NelsonVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Michelle JonesVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Leslie R BooneVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Colleen LawrenceVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Sarah K CookVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Tiffany ChenVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Jodie CohenVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Natalie DiltsVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA.
Alex C ChengVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Randall W GroutIndiana University School of Medicine, Indianapolis, IN, USA; The Regenstrief Institute, Inc., Indianapolis, IN, USA.
Edgar R MillerJohns Hopkins University School of Medicine, Baltimore, MD, USA.
James F CasellaJohns Hopkins Institute for Clinical and Translational Research, Baltimore, MD, USA; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel K BenjaminDuke University School of Medicine, Durham, NC, USA.
Harry P SelkerInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA; Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.
Marisha E PalmInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA; Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.
Lori PooleDuke Clinical Research Institute, Durham, NC, USA.
Jeri S BurrUniversity of Utah Health, Salt Lake City, UT, USA.
Daniel E FordJohns Hopkins Institute for Clinical and Translational Research, Baltimore, MD, USA; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gordon R BernardVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Paul A HarrisVanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Catalyzing and Harmonizing Operational Innovation for Recruitment (CHOIR)U24TR004432 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, CONSUELO HOPKINS WILKINS · 2023 to 2026
$20.9M
Engaging Cooperative Sites for Trial Acceleration, Trust, Innovation, and Capability (ECSTATIC)U24TR004437 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Gordon Raphael Bernard, Jonathan Dale Casey · 2023 to 2026
$19.9M
Johns Hopkins University Trial Innovation CenterU24TR004440 · NCATS · JOHNS HOPKINS UNIVERSITY · PI DANIEL F HANLEY · 2023 to 2026
$19.6M
NCATS NIH HHS U24 TR004432NCATS NIH HHS U24 TR004437NCATS NIH HHS U24 TR004440
6 · The paper itself

Abstract

Effective design and execution of multicenter clinical trials remain critical yet challenging for advancing clinical care. The Trial Innovation Network (TIN) Comprehensive Consultation process was established to improve the feasibility and success of investigator-initiated trial proposals by offering structured, multidisciplinary support across 60+ Clinical and Translational Science Award (CTSA) institutions. We report outcomes from 75 trial proposals that underwent Comprehensive Consultation between 2016 and 2024. The process follows a phased Assess-Design-Compose model that integrates expertise in trial design, operations, recruitment, and informatics to generate robust, fundable grant applications. Here we demonstrate 66% of our submitted grants receive funding. This consultation framework demonstrates a scalable, high-impact approach to enhancing the rigor, efficiency, and success of multicenter clinical trials and offers a model for national and global networks seeking to improve clinical research translation.

Indexed as

Clinical Trials as TopicMulticenter Studies as TopicReferral and ConsultationResearch DesignTranslational Research, BiomedicalHumansTranslational Science, BiomedicalClinical trialsInformative researchMedicineResearch ethicsTrial innovation network

Identifiers

PMID42086122
PMCPMC13237878

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.