Evidence map›Paper›PMID 42085865›Full record

ArticleRedox biology2026

Hydropersulfides promote angiogenesis and preserve vascular function.

Reece J Lamb, Fifi S Ibrahim, Vinayak S Khodade, Scott P Davies, Kayleigh Griffiths, Tsuyoshi Takata, Jinjing Gu, Tetsuro Matsunaga, Roger J Grand, Francesca M Nichols and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Reece J LambDepartment of Cardiovascular Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, United Kingdom.
Fifi S IbrahimDepartment of Cardiovascular Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, United Kingdom.
Vinayak S KhodadeDepartment of Chemistry, Johns Hopkins University, Baltimore, MD, USA.
Scott P DaviesDeparment of Inflammation and Immunotherapy, School of Infection, Inflammation, and Immunology, College of Medicine and Health, University of Birmingham, United Kingdom.
Kayleigh GriffithsDepartment of Cardiovascular Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, United Kingdom.
Tsuyoshi TakataDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.
Jinjing GuDepartment of Chemistry, Johns Hopkins University, Baltimore, MD, USA.
Tetsuro MatsunagaDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.
Roger J GrandDepartment of Cardiovascular Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, United Kingdom.
Francesca M NicholsDepartment of Cardiovascular Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, United Kingdom.
Alice J BartonDepartment of Cardiovascular Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, United Kingdom.
Aisah A AubdoolWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Barts & The London Hospitals, Queen Mary University of London, United Kingdom.
Masanobu MoritaDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.
Hozumi MotohashiDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.
Ming XianDepartment of Chemistry, Brown University, Providence, RI, USA.
Takaaki AkaikeDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.
John P ToscanoDepartment of Chemistry, Johns Hopkins University, Baltimore, MD, USA. Electronic address: jtoscano@jhu.edu.
Melanie MadhaniDepartment of Cardiovascular Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, United Kingdom; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore. Electronic address: m.madhani@bham.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydropersulfides (RSSH) are increasingly recognized as key mediators in redox signalling in mammalian cells, although their physiological functions, especially in angiogenesis, remain unknown. Direct mechanistic investigation of RSSH has been challenging due to their instability and high reactivity. To address this, donors that release RSSH in a controlled manner have been developed, enabling investigation of its biological roles. Herein, we employed thiol- and enzyme-activated RSSH donors along with mutant mouse models deficient in the Cys-SSH-producing enzyme cysteinyl-tRNA synthetase/cysteine persulfide synthase (CARS2/CPERS), to examine their role in vascular angiogenesis. We demonstrate that RSSH promotes angiogenesis via the CARS2/CPERS signalling axis and activation of the Akt-eNOS and NO-cGMP pathway. We also demonstrate that nitric oxide (NO) signalling in resistance vessels requires an intact CARS2/CPER2 pathway. These findings suggest that RSSH plays an important role in regulating angiogenesis and vascular tone.

Indexed as

Neovascularization, PhysiologicSulfidesAnimalsCyclic GMPHumansMiceNitric OxideNitric Oxide Synthase Type IIIProto-Oncogene Proteins c-aktSignal TransductionCyclic GMPNitric OxideNitric Oxide Synthase Type IIIProto-Oncogene Proteins c-aktSulfides

Identifiers

PMID42085865
PMCPMC13158569

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.