Evidence map›Paper›PMID 42085864›Full record

ArticleRedox biology2026

Cytosolic PRDX1 acts as an extramitochondrial sink to set mitochondrial H

Lianne Jhc Jacobs, Sebastian Doll, Dietrich Trümbach, Matteo Veronese, Giada Di Pietro, Fatma Isil Yapici, Lidwina Hasberg, Pascal Gentzsch, Sarah Gerlich, Jens Hansen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lianne Jhc JacobsRedox Metabolism Group, Institute for Biochemistry, University of Cologne, Cologne, 50674, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Sebastian DollHelmholtz Zentrum München, Institute of Metabolism and Cell Death, Neuherberg, 85764, Germany.
Dietrich TrümbachHelmholtz Zentrum München, Institute of Metabolism and Cell Death, Neuherberg, 85764, Germany.
Matteo VeroneseCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany; Institute for Genetics, University of Cologne, Cologne, 50674, Germany.
Giada Di PietroCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany; Institute for Genetics, University of Cologne, Cologne, 50674, Germany.
Fatma Isil YapiciCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, 50931, Germany.
Lidwina HasbergRedox Metabolism Group, Institute for Biochemistry, University of Cologne, Cologne, 50674, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Pascal GentzschRedox Metabolism Group, Institute for Biochemistry, University of Cologne, Cologne, 50674, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Sarah GerlichRedox Metabolism Group, Institute for Biochemistry, University of Cologne, Cologne, 50674, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Jens HansenHelmholtz Zentrum München, Institute of Metabolism and Cell Death, Neuherberg, 85764, Germany.
Silvia von KarstedtCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, 50931, Germany.
Elena I RugarliCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany; Institute for Genetics, University of Cologne, Cologne, 50674, Germany; Center for Molecular Medicine, University of Cologne, 50931 Germany.
Marcus ConradHelmholtz Zentrum München, Institute of Metabolism and Cell Death, Neuherberg, 85764, Germany; Translational Redox Biology, Technical University of Munich (TUM), TUM Natural School of Sciences, Garching, 85748, Germany.
Armindo SalvadorCNC-UC - Centre for Neuroscience Cell Biology, University of Coimbra, Coimbra, 3004-504, Portugal; CiBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, 3004-504, Portugal; Coimbra Chemistry Center - Institute of Molecular Sciences (CQC-IMS), University of Coimbra, Coimbra, 3004-535, Portugal; Institute for Interdisciplinary Research, University of Coimbra, Coimbra, 3030-789, Portugal.
Jan RiemerRedox Metabolism Group, Institute for Biochemistry, University of Cologne, Cologne, 50674, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany; Center for Molecular Medicine, University of Cologne, 50931 Germany. Electronic address: jan.riemer@uni-koeln.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogen peroxide (H

Indexed as

CytosolHydrogen PeroxideMitochondriaOxidative StressPeroxiredoxinsHEK293 CellsHumansMitophagyHydrogen PeroxidePeroxiredoxinsPRDX1 protein, human

Identifiers

PMID42085864
PMCPMC13158620

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.