ArticleGenetics2026
Comparative genomic analysis and epigenetic profiling of the Drosophila melanogaster B chromosome.
Article in Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Highlighting the genetics of natural and synthetic selfish elements in a special GENETICS and G3 series.Genetics · 2026Article
- Highlighting the genetics of natural and synthetic selfish elements in a special GENETICS and G3 series.G3 (Bethesda, Md.) · 2026Article
- The enigma of the B chromosome-specific behaviour.Frontiers in plant science · 2026Review
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7 authors.
Funding
Abstract
Supernumerary B chromosomes have been identified in hundreds of species across many different taxa, each with their own evolutionary history, unique sequence composition, and epigenetic profile. In this study, we generated a detailed repetitive sequence and epigenetic landscape of the B chromosomes in Drosophila melanogaster. By comparing the repetitive DNA content of stocks with (+B) and without (0B) B chromosomes, we found 9 satellite DNA (satDNA) sequences that were enriched in the +B genome, 3 of which were cytogenetically confirmed to be on the B chromosomes. Our satDNA analysis also led to the discovery of 3 novel satDNA repeats that are not on the B chromosomes and have not been described previously (Sat-307, Sat-597, and Sat-228). Analysis of transposable elements (TEs) revealed that although TEs comprise similar proportions of the 0B and +B genomes, the centromeric transposon G2/Jockey is modestly enriched in the +B genome, consistent with the high number of centromeres present in the +B genome. We also immunostained both male somatic and germline tissues to gain insight into the epigenetic state of the B chromosomes and found the presence of heterochromatin-associated histone modifications (H3K9me1, H3K9me2), a lack of acetylation (H4K5ac), and the absence of RNA polymerase II in the B chromosome nuclear territory, suggesting the B chromosomes have a reduced level of transcription. Together, our work further defines the genetic composition of the D. melanogaster B chromosome and establishes its epigenetic profile, which will provide a foundation for future work investigating changes to repetitive DNA over time and how a transcriptionally repressed chromosome influences chromatin maintenance in the genome.
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