Evidence map›Paper›PMID 42085559›Full record

ArticleMolecular biology and evolution2026

IQ-TREE 3: phylogenomic inference software using complex evolutionary models.

Thomas K F Wong, Nhan Ly-Trong, Huaiyan Ren, Piyumal Demotte, Hector Baños, Andrew J Roger, Edward Susko, Chris Bielow, Nicola De Maio, Nick Goldman and 6 more

Abstract read
In one paragraph

Article in Molecular biology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 368 papers.

0numbers the graph read from it
0cells of the map it votes in
368citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

368 citing papers in PubMed.

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  14. Novel AfricanJournal of virology · 2026
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  16. Novel Thermophilic Species ofLife (Basel, Switzerland) · 2026
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  20. Molecular dockingDigital discovery · 2026
    Article

308 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Thomas K F WongSchool of Computing, College of Systems and Society, Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-0580-6324
Nhan Ly-TrongSchool of Computing, College of Systems and Society, Australian National University, Canberra, ACT, Australia.ORCID 0000-0001-5668-5027
Huaiyan RenSchool of Computing, College of Systems and Society, Australian National University, Canberra, ACT, Australia.ORCID 0009-0009-2870-3481
Piyumal DemotteSchool of Computing, College of Systems and Society, Australian National University, Canberra, ACT, Australia.ORCID 0000-0001-8144-580X
Hector BañosDepartment of Mathematics, California State University San Bernardino, San Bernardino, CA, USA.ORCID 0000-0001-5769-2544
Andrew J RogerDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0003-1370-9820
Edward SuskoDepartment of Mathematics and Statistics, Faculty of Science, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0003-1122-8740
Chris BielowBioinformatics Solution Center, Freie Universität Berlin, Berlin 14195, Germany.ORCID 0000-0001-5756-3988
Nicola De MaioEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, UK.ORCID 0000-0002-1776-8564
Nick GoldmanEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, UK.ORCID 0000-0001-8486-2211
Matthew W HahnDepartment of Biology and Department of Computer Science, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0002-5731-8808
Mario Dos ReisSchool of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, UK.ORCID 0000-0001-9514-3976
Le Sy VinhUniversity of Engineering and Technology, Vietnam National University, Hanoi, Vietnam.ORCID 0000-0002-9060-9199
Gavin HuttleyResearch School of Biology, College of Science and Medicine, Australian National University, Canberra, ACT, Australia.ORCID 0000-0001-7224-2074
Robert LanfearResearch School of Biology, College of Science and Medicine, Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-1140-2596
Bui Quang MinhSchool of Computing, College of Systems and Society, Australian National University, Canberra, ACT, Australia.ORCID 0000-0002-5535-6560

Funding

ANU Merit Allocation SchemeAustralian Government through the National Computational InfrastructureAustralian Research Council Discovery Project DP200103151Australian Research Council Training Centre for Accelerated Future Crops Development IC210100047Center for Integrative Bioinformatics ViennaChan-Zuckerberg Initiative EOSS-0000000132Chan-Zuckerberg Initiative EOSS4-0000000312Chan-Zuckerberg Initiative EOSS5-0000000223European Molecular Biology Laboratory and by MRC-NIHR Better Methods, Better Research MR/Z503526/1Natural Sciences and Engineering Research Council of Canada DiscoverySimons Moore FoundationU.K. Biotechnology and Biological Sciences Research Council BB/T01282X/1U.S. National Science Foundation DBI-2146866U.S. National Science Foundation DMS-2331660Vietnam National Foundation for Science and Technology Development 102.05-2025.65
6 · The paper itself

Abstract

IQ-TREE (https://iqtree.github.io/) is a widely used open-source software tool for efficiently inferring phylogenetic trees under maximum likelihood. Here, we present IQ-TREE version 3, the third major release of the software. IQ-TREE 3 significantly extends version 2 with new features, including mixture models as an alternative to partitioned models, gene and site concordance factors to quantify discordance between genomic regions, integration with phylogenomic divergence time estimation, and a fully featured sequence simulator. The IQ-TREE 3 source code is available at https://github.com/iqtree/iqtree3.

Indexed as

Models, GeneticPhylogenySoftwareEvolution, MolecularGenomicsLikelihood Functionsconcordance factormaximum likelihoodmixture modelphylogenetic softwarephylogenomic softwaresequence simulator

Identifiers

PMID42085559
PMCPMC13191116

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.