Evidence map›Paper›PMID 42085495›Full record

ArticleOrganic letters2026

Molecular Editing of Bilobalide: Regioselective C-Ring Lactam Formation.

Wenjing Wang, Stephan Scheeff, Sam Chun-Kit Hau, Yao Qin, Chanin Sillapachaiyaporn, Billy Wai-Lung Ng

Abstract read
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenjing WangSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.ORCID 0009-0008-4110-9754
Stephan ScheeffSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0001-7791-9670
Sam Chun-Kit HauDepartment of Chemistry, Faculty of Science, The Chinese University of Hong Kong, Shatin, Hong Kong.ORCID 0000-0003-4774-0447
Yao QinSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Chanin SillapachaiyapornSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Billy Wai-Lung NgSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0003-2892-6318

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late-stage diversification of complex natural products enables rapid access to analogues for structure-activity relationship studies. Herein, we report a regioselective lactone-to-lactam editing strategy for bilobalide, affording previously inaccessible C-ring lactam analogues. The transformation proceeds through

Indexed as

Biological ProductsBridged-Ring CompoundsCyclopentanesFuransLactamsCyclizationGinkgolidesLactonesMolecular StructureStereoisomerismStructure-Activity RelationshipbilobalideBiological ProductsBridged-Ring CompoundsCyclopentanesFuransGinkgolidesLactamsLactones

Identifiers

PMID42085495
PMCPMC13185091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.