Evidence map›Paper›PMID 42084823›Full record

ReviewPharmacological reports : PR2026

Prospects and challenges in intracellular delivery of therapeutic proteins.

Zakia Sultana, Ashif Ahamed, Muddasarul Hoda, Safdar Ali, Mehboob Hoque

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pharmacological reports : PR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zakia SultanaApplied Biochemistry Laboratory, Department of Biological Sciences, Aliah University, Kolkata, 700160, India.
Ashif AhamedApplied Biochemistry Laboratory, Department of Biological Sciences, Aliah University, Kolkata, 700160, India.
Muddasarul HodaNanobiotechnology and Applied Phytochemistry Laboratory, Department of Biological Sciences, Aliah University, Kolkata, 700160, India.
Safdar AliClinical and Applied Genomics Laboratory, Department of Biological Sciences, Aliah University, Kolkata, 700160, India.
Mehboob HoqueApplied Biochemistry Laboratory, Department of Biological Sciences, Aliah University, Kolkata, 700160, India. m_hoque@aliah.ac.in.ORCID https://orcid.org/0000-0001-8450-7738

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small-molecule drugs have gained significant interest in therapeutic development. However, their therapeutic efficacy is often limited by poor target specificity, low bioavailability, and increased toxicity at higher doses. In recent years, biomolecule-based therapeutics such as proteins and peptides have emerged as promising alternatives due to their high specificity, solubility, and low toxicity. Despite these advantages, the intracellular delivery of these molecules remains challenging due to their poor stability, short half-life, and endo-lysosomal entrapment. Several delivery strategies have been developed to overcome these limitations, such as chemical modifications, structural modifications like poly(ethylene glycol) conjugation (PEGylation), and advanced carrier systems such as cell-penetrating peptides (CPPs), nanoparticles (NPs), functional polymers, and antibody-based delivery systems. Non-viral delivery systems have gained considerable attention due to their biocompatibility, low toxicity, and relatively high efficiency. This review provides a comprehensive overview of the various intracellular delivery strategies of therapeutic proteins, highlighting their mechanisms of cellular uptake, advantages, limitations, and future perspectives in biomedical applications.

Indexed as

Drug Delivery SystemsProteinsAnimalsCell-Penetrating PeptidesDrug CarriersHumansNanoparticlesPolyethylene GlycolsPolymersCell-Penetrating PeptidesDrug CarriersPolyethylene GlycolsPolymersProteins

Identifiers

PMID42084823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.