Evidence map›Paper›PMID 42084812›Full record

ArticleProbiotics and antimicrobial proteins2026

Lactiplantibacillus plantarum Mediated Tryptophan Metabolism to Alleviate Tropomyosin-induced Food Allergy.

Jing Ma, Pengyan Tong, Kang Yang, Yining Jia, Zhen Liu, Mengya Zhao, Jing Liu, Fangyu Long

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing MaCollege of Foods Science and Engineering, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China.
Pengyan TongCollege of Foods Science and Engineering, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China.
Kang YangZhejiang Delthin Food Technology Co., Ltd., Jiaxing, 314001, China.
Yining JiaCollege of Foods Science and Engineering, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China.
Zhen LiuCollege of Foods Science and Engineering, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China.
Mengya ZhaoCollege of Foods Science and Engineering, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China.
Jing LiuInstitute of Animal Husbandry and Veterinary Medicine, Guizhou Academy of Agricultural Sciences, Guiyang, 550005, China.
Fangyu LongCollege of Foods Science and Engineering, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China. fangyu315@126.com.

Funding

Guizhou Provincial Science and Technology Programme for Outstanding Young Talents in Science and Technology YQK[2023]020Key Research and Development Projects of Shaanxi Province 2024NC-GJHX-04National Natural Science Fund 32472454
6 · The paper itself

Abstract

Food allergy (FA) has become increasingly prevalent, affecting daily life. Probiotics alleviate FA by modulating immune-microbiome interactions. Nevertheless, the key metabolites and mechanisms by which L. plantarum alleviates FA remain unclear. In this study, L. plantarum demonstrated the ability to improve FA by modulating regulatory T/Th1/Th2 balance, modulating gut microbial composition, and regulating gut metabolites. Tropomyosin sensitization was associated with decreased levels of 5-hydroxyindole-3-acetic acid (5-HIAA) in cecum contents, a phenomenon also observed in the serum of FA mice and patients. In vitro experiments showed that tryptophan (Trp), tryptamine, tryptophol, kynurenine, 5-HIAA, and indole-3-acetamide inhibited RBL-2H3 cell degranulation; however, this inhibitory effect was attenuated by the aryl hydrocarbon receptor (AhR) antagonist CH223191. Moreover, in vivo results indicated that dietary supplementation with 5-HIAA or Trp downregulated IgE and cytokine levels in an AhR-dependent manner. This study provided evidence for the positive role of Trp metabolites in alleviating FA.

Indexed as

Food HypersensitivityLactiplantibacillus plantarumProbioticsTropomyosinTryptophanAnimalsFemaleHumansImmunoglobulin EMaleMiceMice, Inbred BALB CReceptors, Aryl HydrocarbonImmunoglobulin EReceptors, Aryl HydrocarbonTropomyosinTryptophan5-HIAAAhRFood allergyL. PlantarumTryptophan metabolism

Identifiers

PMID42084812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.