Evidence map›Paper›PMID 42084621›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Chrysophanol ameliorates ferroptosis in acute kidney injury by promoting SIRT3-mediated NRF2 deacetylation.

Mengdi Cui, Hao Tian, Jinyue Zhu, Jing Zhu, Qiyuan Wang, Yinshui Zou

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mengdi Cui *The First Clinical College, Hubei University of Chinese Medicine, Wuhan, China.
Hao Tian *Hubei Provincial Hospital of Traditional Chinese Medicine, 4 Garden 14 Hill Road, Wuchang District, Wuhan, 430000, Hubei, China.
Jinyue Zhu *Hubei Provincial Hospital of Traditional Chinese Medicine, 4 Garden 14 Hill Road, Wuchang District, Wuhan, 430000, Hubei, China.
Jing ZhuHubei Provincial Hospital of Traditional Chinese Medicine, 4 Garden 14 Hill Road, Wuchang District, Wuhan, 430000, Hubei, China. zhujing@hbhtcm.com.
Qiyuan WangHubei Provincial Hospital of Traditional Chinese Medicine, 4 Garden 14 Hill Road, Wuchang District, Wuhan, 430000, Hubei, China. 149806520@qq.com.
Yinshui ZouHubei Provincial Hospital of Traditional Chinese Medicine, 4 Garden 14 Hill Road, Wuchang District, Wuhan, 430000, Hubei, China. zouyinshui@hbhtcm.com.

Funding

Innovation and Development Joint Fund Project of Hubei Provincial Natural Science Foundation Nos. 2022CFD023Innovation and Development Joint Fund Project of Hubei Provincial Natural Science Foundation Nos. 2025AFD478Traditional Chinese Medicine Research Project of Hubei Provincial Administration of Traditional Chinese Medicine Nos. ZY2025L243Traditional Chinese Medicine Research Project of Hubei Provincial Administration of Traditional Chinese Medicine Nos. ZY2025M031
6 · The paper itself

Abstract

Ferroptosis is a critical driver of renal tubular cell death in acute kidney injury (AKI). The present study aimed to investigate the protective effects of chrysophanol (CHR) against AKI-associated ferroptosis and delineate the mechanistic pathway involving Sirtuin 3 (SIRT3)-mediated deacetylation of NRF2. AKI was induced by lipopolysaccharide (LPS) in wild-type (WT) and SIRT3 knockout (SIRT3

Indexed as

Acute Kidney InjuryFerroptosisNF-E2-Related Factor 2Sirtuin 3AcetylationAnimalsAnthraquinonesAnti-Inflammatory AgentsLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, KnockoutAnthraquinonesAnti-Inflammatory Agentschrysophanic acidLipopolysaccharidesNfe2l2 protein, mouseNF-E2-Related Factor 2Sirt3 protein, mouseSirtuin 3Acute kidney injuryDeacetylationFerroptosisSIRT3

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.