Pluronic F127-functionalized cerium fluoride nanocomposite: synthesis, characterization, and its enhanced antibacterial activities.

Shashikala A R, Sarita Chaudhary, Shaikh Adil, Sudhanshu Rout, Indumathi Thangavelu, Srinivas Tadepalli, Abdelrahman G Gadallah

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Shashikala A RDepartment of Chemistry, Presidency University, Bengaluru, 560064, Karnataka, India.

Sarita ChaudharyDepartment of FBAS (Chemistry), Vivekananda Global University, Jaipur, 303012, India.

Shaikh AdilDepartment of Dairy Technology, Faculty of Engineering and Technology, Parul Institute of Technology, Parul University, Vadodara, 391760, Gujarat, India.

Sudhanshu RoutDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to Be University), Bhubaneswar, 751030, Odisha, India.

Indumathi ThangaveluDepartment of Chemistry, CHRIST (Deemed to Be University), Bangalore, 560029, India.

Srinivas TadepalliDepartment of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia.

Abdelrahman G GadallahDepartment of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia. Agadallah@imamu.edu.sa.

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6 · The paper itself

Abstract

The persistence of pathogenic bacteria, rising antibiotic resistance, and the ongoing need for effective anticancer agents necessitate the development of advanced multifunctional therapeutic strategies. In this study, CeF₃ nanoparticles and PF127-functionalized CeF₃ (CeF₃-PF127) nanocomposites were synthesized via a facile wet chemical route and systematically characterized for their structural, optical, and biological properties. XRD confirmed the formation of phase-pure hexagonal CeF₃ with crystallite sizes of 31 nm (CeF₃) and 27 nm (CeF₃-PF127), while SAED revealed lattice fringes of approximately 0.27 nm (CeF₃) and 0.29 nm (CeF₃-PF127). EDAX and XPS validated the Ce/F stoichiometry and the successful surface functionalization with PF127. Optical analyses showed a slight reduction in band gap from 3.15 to 3.09 eV upon polymer coating, and PL spectra indicated enhanced defect-related emission in CeF₃-PF127, suggesting stabilization of Ce

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsCeriumFluoridesNanocompositesPoloxamerAnimalsAntioxidantsBiphenyl CompoundsCell Line, TumorCell SurvivalHumansMicrobial Sensitivity TestsPicratesAnti-Bacterial AgentsAntineoplastic AgentsAntioxidantsBiphenyl CompoundsCeriumcerium fluorideFluoridesPicratesPoloxamerAntibacterial and anticancer activityAntioxidant propertiesBiocompatible nanomaterialsCeF₃ nanoparticlesCeF₃–PF127 nanocomposite

Identifiers

PMID42084618

DOI10.1007/s00210-026-05398-3

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