Evidence map›Paper›PMID 42084500›Full record

ArticleGut microbes2026

Altered crosstalk of bacterial lipopolysaccharide with immune cells in colorectal cancer compared to paired adjacent intestinal tissue.

Åsa Walberg, Anna Maria Reuss, Reihane Ziadlou, Céline Mamie, Claudia Gottier, Anna White, Mohammadmilad Ameri, Marie-Charlotte Brüggen, Matthias Turina, Michaela Ramser and 8 more

Abstract read
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In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Åsa WalbergDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Anna Maria ReussInstitute of Neuropathology, University Hospital Zurich, University of Zurich, and ZNZ Neuroscience Center, Zurich, Switzerland.
Reihane ZiadlouDepartment of Dermatology, University of Zurich, Zurich, Switzerland.
Céline MamieDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Claudia GottierDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Anna WhiteDepartment of Dermatology, University of Zurich, Zurich, Switzerland.
Mohammadmilad AmeriDepartment of Dermatology, University of Zurich, Zurich, Switzerland.
Marie-Charlotte BrüggenDepartment of Dermatology, University of Zurich, Zurich, Switzerland.
Matthias TurinaDepartment of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland.
Michaela RamserDepartment of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland.
Paulina WawrzyniakDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-9641-2103
Maria WalkerDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Luca TruscelloDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Adriano AguzziInstitute for the Science of the Aging Brain (ISAB), St. Gallen, Switzerland.
Anne MüllerInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Barbara HubeliDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Yasser MorsyDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8234-1877
Michael ScharlDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-6729-1469

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Commensal bacteria play a crucial role in modulating human immune responses in the intestine. Under homeostatic conditions, the gut microbiota is tightly regulated by interactions with the mucosal immune system. However, colorectal cancer (CRC) is characterized by an imbalance in bacterial composition and bacterial translocation across the intestinal barrier. The spatial distribution of bacteria and their interactions with immune cells in CRC tumors are poorly understood. By applying 3D light-sheet imaging, spatial transcriptomics, and imaging mass cytometry to patient-derived CRC and adjacent intestinal tissue, bacterial lipopolysaccharide (LPS) can be visualized alongside immune cells and vessels. The results showed regional bacterial LPS accumulation and colocalization with distinct immune cell subsets. In CRC-adjacent tissue, bacterial LPS is mainly associated with CD11c

Indexed as

BacteriaColorectal NeoplasmsGastrointestinal MicrobiomeIntestinal MucosaLipopolysaccharidesDendritic CellsFemaleHumansMacrophagesMaleNeutrophilsLipopolysaccharides3D imagingadapted iDISCObacterial-immune interactionsbacterial lipopolysaccharide (LPS)colorectal cancerGut microbiotaimaging mass cytometryspatial transcriptomicstumor microenvironment

Identifiers

PMID42084500
PMCPMC13154938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.