Evidence map›Paper›PMID 42084394›Full record

ArticlemBio2026

Multi-omics profiling of fungal balls in chronic pulmonary aspergillosis patients reveals microbiome dynamics and metabolic adaptations.

Chan Liu, Matheus Mertz Ribeiro, Jian Yang, Liangyu Li, Jianxiong Li, Xianqiu Chen, Yude Wang, Le-Le Wang, Beibei Wang, Yiming Zhou and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chan Liu *Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0009-0002-9373-8938
Matheus Mertz Ribeiro *Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Jian Yang *Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Liangyu LiDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Jianxiong LiDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xianqiu ChenDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yude WangDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Le-Le WangDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Beibei WangDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yiming ZhouDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine,Tongji University, Shanghai, China.
Jing ZhangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine,Tongji University, Shanghai, China.
Jijin JiangDepartment of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.
Jielu LinDepartment of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Endrews DelbajeDepartamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-0313-9046
Jin-Fu XuInstitute of Respiratory Medicine, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-8039-8973
Gustavo H GoldmanFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-2986-350X
Shuo LiangDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0003-4748-2724

Funding

Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5M
National Natural Science Foundation of China No. 82170051NIAID NIH HHS R01 AI153356
6 · The paper itself

Abstract

Fungal balls (aspergillomas) are a debilitating complication of chronic pulmonary aspergillosis, but their functional biology as multi-kingdom ecosystems is poorly understood. Through integrated multi-omics analysis of 61 patient-derived fungal balls, we reveal their complex ecology. While

Indexed as

MicrobiotaPulmonary AspergillosisAspergillus fumigatusBiofilmsChronic DiseaseGene Expression ProfilingHaemophilus influenzaeHumansMetabolomicsMultiomicsPseudomonas aeruginosaaspergillomaAspergillus fumigatuschronic pulmonary aspergillosisHaemophilus influenzaePseudomonas aeruginosa

Identifiers

PMID42084394
PMCPMC13251403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.