Evidence map›Paper›PMID 42084367›Full record

ArticleAntimicrobial agents and chemotherapy2026

Transcriptome-constrained genome-scale metabolic modeling reveals central carbon and amino acid metabolic reprogramming underlying colistin-sulbactam synergy in

Xingchen Bian, Yan Zhu, Xiaofen Liu, Xin Li, Wanzhen Li, Jinxin Zhao, Jian Li, Jing Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Disruption ofVirulence · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xingchen BianClinical Pharmacology Research Center, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-2554-5317
Yan ZhuSystems Biology Center, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.ORCID 0000-0001-7342-3782
Xiaofen LiuInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-5526-1502
Xin LiInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Wanzhen LiInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Jinxin ZhaoInfection Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Jian LiInfection Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0001-7953-8230
Jing ZhangClinical Pharmacology Research Center, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-2966-9149

Funding

National Natural Science Foundation of China 82173896Shanghai Science and Technology Development Foundation 23YF1404000
6 · The paper itself

Abstract

This study aimed to construct a genome-scale metabolic model (GSMM) for

Indexed as

Acinetobacter baumanniiAmino AcidsAnti-Bacterial AgentsCarbonColistinSulbactamCitric Acid CycleDrug SynergismMetabolic ReprogrammingMicrobial Sensitivity TestsTranscriptomeAmino AcidsAnti-Bacterial AgentsCarbonColistinSulbactambeta-lactam inhibitorcarbapenem-resistant A. baumanniicombination therapyconstraint-based genome-scale metabolic modelflux variability analysispolymyxin

Identifiers

PMID42084367
PMCPMC13231871

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.