ArticleJournal of feline medicine and surgery2026
Serum amyloid A: A biomarker to aid in assessing cats with acute pyelonephritis and monitoring response to antibiotic therapy.
Article in Journal of feline medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
ObjectivesSerum amyloid A (SAA), the major acute-phase protein in cats, has potential, as in humans, to aid in the diagnosis and treatment of bacterial infections. This study compared SAA concentrations in cats with acute pyelonephritis (APN) with stable chronic kidney disease (CKD) and healthy cats. In cats with APN, SAA concentrations were monitored during antibiotic treatment to assess whether they correlated with clinical scores.MethodsA multicenter study recruited client-owned cats with APN (n = 9), with stable CKD (n = 10) or healthy cats (n = 10). Cats with APN were monitored for 21 days during antibiotic therapy to assess SAA concentrations along with clinical scores.ResultsThe majority of cats with APN were older (>10 years) and spayed females (8/10), with 5/9 having pre-existing CKD. Median SAA concentrations were significantly higher in cats with APN (235.3 mg/l, range 9.1-810) than in healthy cats (1.85 mg/l, range 1-2.7;
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