A Stepwise Approach to 1,4,10,13-Tetraaza-18-Crown-6 Ether.

Pieter Troosters, Lara Bruneel, Wim Dehaen, Tomas Opsomer

Abstract read

In one paragraph

Article in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pieter TroostersNuclear Energy Technology, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.ORCID https://orcid.org/0009-0004-4009-0802

Lara BruneelNuclear Energy Technology, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.ORCID https://orcid.org/0009-0005-7827-3433

Wim DehaenDepartment of Chemistry, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-9597-0629

Tomas OpsomerNuclear Medical Applications, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.ORCID https://orcid.org/0000-0002-8272-0292

Funding

KU Leuven C14/19/78

6 · The paper itself

Abstract

A two-step approach to the synthesis of tetraaza-18-crown-6 ether was evaluated to address the limitations of the currently used one-step macrocyclization, such as low yield due to substantial side product formation. In this route, the reaction conditions were optimized, reducing cyclization to the undesired nine-membered ring by a factor of eight. This resulted in a 50% yield for the two-step macrocyclization, or 28% when column chromatography was avoided, both significantly higher than the 16% yield obtained when reproducing the one-step method.

Indexed as

crown compoundsmacrocyclesmacrocyclizationstepwise synthesistetraaza‐18‐crown‐6 ether

Identifiers

PMID42084269

DOI10.1002/open.70201

PMCPMC13140966

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.