Evidence map›Paper›PMID 42084208›Full record

ArticlePediatric blood & cancer2026

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium.

Emily J Mason, John P Woodhouse, Joanna S Yi, M Monica Gramatges, Olga A Taylor, Veronica A Morales, Shalini Dhamodharan, Marley Roberts, Karen R Rabin, Philip J Lupo and 5 more

Abstract read
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In one paragraph

Article in Pediatric blood & cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Emily J MasonBaylor College of Medicine, Houston, Texas, USA.
John P WoodhouseBaylor College of Medicine, Houston, Texas, USA.
Joanna S YiBaylor College of Medicine, Houston, Texas, USA.
M Monica GramatgesBaylor College of Medicine, Houston, Texas, USA.
Olga A TaylorEmory School of Medicine, Atlanta, Georgia, USA.
Veronica A MoralesBaylor College of Medicine, Houston, Texas, USA.
Shalini DhamodharanBaylor College of Medicine, Houston, Texas, USA.
Marley RobertsBaylor College of Medicine, Houston, Texas, USA.
Karen R RabinUniversity of California San Francisco, San Francisco, California, USA.
Philip J LupoEmory School of Medicine, Atlanta, Georgia, USA.
Michael E ScheurerEmory School of Medicine, Atlanta, Georgia, USA.
Van HuynhChildren's Hospital of Orange County (CHOC), Orange, California, USA.
Steven D MittelmanUniversity of California Los Angeles, Los Angeles, California, USA.
Etan OrgelChildren's Hospital of Los Angeles, Los Angeles, California, USA.
Austin L BrownBaylor College of Medicine, Houston, Texas, USA.

Funding

Reducing Disparities in Acute Leukemia (REDIAL) Consortium U54CA302464 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Karen R Rabin · 2025 to 2026
$7.2M
Survivorship and Access to care for Latinos to Understand and Address health outcome Differences (SALUD)UH3CA260607 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Maria Monica Gramatges, LISA SCHUM KAHALLEY · 2023 to 2026
$6.3M
Improving Outcome Disparities for Latino Children and Adolescents with Acute Lymphoblastic LeukemiaP20CA262733 · NCI · BAYLOR COLLEGE OF MEDICINE · PI GRAMATGES, MARIA MONICA · 2021 to 2023
$3.2M
Cancer Prevention and Research Institute of TexasNCI NIH HHS P20 CA262733NCI NIH HHS U54 CA302464NCI NIH HHS UH3 CA260607St. Baldrick's Foundation
6 · The paper itself

Abstract

Treatment-associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele was associated with an increased odds of conjugated hyperbilirubinemia and/or Grade 4 transaminitis in Hispanic children (adjusted odds ratio [aOR] = 2.73, 95% confidence interval [CI]: 1.72-4.47; p = 3.5 × 10

Indexed as

Chemical and Drug Induced Liver InjuryEthnicityPolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaSuperoxide DismutaseAdolescentChildChild, PreschoolFemaleHumansInfantMalePrognosisRisk FactorsSuperoxide Dismutase 2Superoxide DismutaseSuperoxide Dismutase 2acute lymphoblastic leukemiahepatotoxicitypediatric oncology

Identifiers

PMID42084208
PMCPMC13331275

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.