Evidence map›Paper›PMID 42084142›Full record

ArticleJournal of the American Society for Mass Spectrometry2026

Native Mass Spectrometry Reveals Binding Modes of the Tumor Suppressor Protein p53 to Different DNA Response Elements.

Erik Siefke, Christian Arlt, Andrea Sinz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Erik SiefkeDepartment of Pharmaceutical Chemistry and Bioanalytics, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Christian ArltDepartment of Pharmaceutical Chemistry and Bioanalytics, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Andrea SinzDepartment of Pharmaceutical Chemistry and Bioanalytics, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.ORCID 0000-0003-1521-4899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We used native mass spectrometry (MS) to investigate how the architecture of the p21 DNA response element (DNA-RE) controls the binding mode of the tumor suppressor protein p53. We analyzed tetrameric full-length wild-type p53 and compared its DNA binding behavior with a dimeric variant, p53

Indexed as

DNAMass SpectrometryResponse ElementsTumor Suppressor Protein p53Binding SitesHumansProtein BindingProtein MultimerizationDNATumor Suppressor Protein p5320-bpbindingDNADNA-REisolatedMSnativep21p53p53:DNAtetrameric

Identifiers

PMID42084142
PMCPMC13237773

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.