Evidence map›Paper›PMID 42084104›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Associations of sleep behaviors with white matter hyperintensity volume in middle-aged to older adults.

Madeline Ally, Daniel H Aslan, M Katherine Sayre, Pradyumna K Bharadwaj, Silvio Maltagliati, Matthew D Grilli, Mark H C Lai, Rand R Wilcox, Yann C Klimentidis, David A Raichlen and 1 more

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Madeline AllyDepartment of Psychology, University of Arizona, Tucson, Arizona, USA.
Daniel H AslanHuman and Evolutionary Biology Section, Department of Biology, University of Southern California, Los Angeles, California, USA.
M Katherine SayreHuman and Evolutionary Biology Section, Department of Biology, University of Southern California, Los Angeles, California, USA.
Pradyumna K BharadwajDepartment of Psychology, University of Arizona, Tucson, Arizona, USA.
Silvio MaltagliatiHuman and Evolutionary Biology Section, Department of Biology, University of Southern California, Los Angeles, California, USA.
Matthew D GrilliDepartment of Psychology, University of Arizona, Tucson, Arizona, USA.
Mark H C LaiDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Rand R WilcoxDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Yann C KlimentidisDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, USA.
David A RaichlenHuman and Evolutionary Biology Section, Department of Biology, University of Southern California, Los Angeles, California, USA.
Gene E AlexanderDepartment of Psychology, University of Arizona, Tucson, Arizona, USA.

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9M
Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared Photobiomodulation: Diversity SupplementR01AG064587 · NIA · UNIVERSITY OF FLORIDA · PI ALEXANDER, GENE E, BOWERS, DAWN · 2019 to 2023
$4.0M
Inactivity, sedentary behavior, and the risk for Alzheimer’s disease in middle aged to older adultsR01AG072445 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GENE E ALEXANDER, Yann Charles Klimentidis · 2022 to 2026
$3.3M
Physical activity predictors of cognitive and brain health in the risk for Alzheimer's diseaseR56AG067200 · NIA · UNIVERSITY OF ARIZONA · PI ALEXANDER, GENE E, RAICHLEN, DAVID · 2020 to 2020
$767k
McKnight Brain Research FoundationNIA NIH HHS P30 AG019610NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG064587NIA NIH HHS R01 AG072445NIA NIH HHS R56 AG067200NIH HHS P30AG019610NIH HHS P30AG072980NIH HHS R01AG064587NIH HHS R01AG072445NIH HHS R56AG067200State of Arizona and Arizona Department of Health Services
6 · The paper itself

Abstract

introductionPoor sleep has been associated with elevated dementia risk, potentially related to its cerebrovascular consequences, measured by cerebral white matter hyperintensity (WMH) volume.

methodsWe examined self-reported sleep behaviors and prospective magnetic resonance imaging (MRI) WMH volume, measured 8.8 ± 1.7 (mean ± SD) years later, in 23,377 healthy UK Biobank participants. Each sleep behavior was adjusted for demographic, imaging, and clinical covariates (Model 1), as well as vascular health and lifestyle factors (Model 2), and significant sleep behaviors were then mutually adjusted.

resultsIn Model 1, all poor sleep behaviors were associated with greater WMH volume. In Model 2, only sleep duration outside 7-9 h (β = 0.015, false discovery rate [FDR]p = 0.014), increased daytime napping (β = 0.018, FDRp = 0.008), and greater sleeplessness (β = 0.015, FDRp = 0.014) were associated with greater WMH volume, with each behavior demonstrating distinct contributions (0.004 ≤ FDRp's ≤ 0.025). DISCUSSION: Self-reported sleep behaviors were prospectively associated with greater WMH volume, suggesting a potential sleep-related pathway influencing vascular brain health and dementia risk.

Indexed as

BrainSleepSleep Wake DisordersWhite MatterAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesSelf ReportSleep DurationUK Biobankbrain agingdementia risksleep qualityUK Biobankwhite matter hyperintensity volume

Identifiers

PMID42084104
PMCPMC13140584

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.