Evidence map›Paper›PMID 42084033›Full record

ArticleBiomaterials science2026

A GMP-compliant formulation of regeneratively active polyphosphate for wound healing and skin regeneration.

Werner E G Müller, Meik Neufurth, Xiaoqin La, Hadrian Nassabi, Mathias Brösicke, Rita Dobmeyer, Rafael Muñoz-Espí, Changxin Wu, Hiroshi Ushijima, Heinz C Schröder and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Werner E G MüllerERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128 Mainz, Germany. wmueller@uni-mainz.de.ORCID http://orcid.org/0000-0002-8223-3689
Meik NeufurthERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128 Mainz, Germany. wmueller@uni-mainz.de.ORCID http://orcid.org/0000-0002-2383-6412
Xiaoqin LaInstitutes of Biomedical Sciences, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education of China and Key Laboratory of Medical Molecular Cell Biology of Shanxi Province, Shanxi University, No. 92 Wucheng Road, 030006 Taiyuan, China.ORCID http://orcid.org/0009-0009-1314-4314
Hadrian NassabiDepartment of Dermatology with Plastic Surgery, SRH Wald-Klinikum Gera GmbH, Friedens Street 122, D-07548 Gera, Germany.ORCID http://orcid.org/0000-0001-8217-5645
Mathias BrösickeAcademy of Non-Profit Sciences in Erfurt, Gotthardt Street 21, 99084 Erfurt, Germany.
Rita DobmeyerGalenus GH AG, Rain Street 7, 6052 Hergiswil, Switzerland.
Rafael Muñoz-EspíInstitute of Materials Science (ICMUV), Universitat de València, C/Catedràtic José Beltrán 2, 46980 Paterna - València, Spain.ORCID http://orcid.org/0000-0002-8146-2332
Changxin WuInstitutes of Biomedical Sciences, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education of China and Key Laboratory of Medical Molecular Cell Biology of Shanxi Province, Shanxi University, No. 92 Wucheng Road, 030006 Taiyuan, China.ORCID http://orcid.org/0000-0002-7416-1662
Hiroshi UshijimaDivision of Microbiology, Department of Pathology and Microbiology, Nihon University-School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-Ku, 173-2610, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4378-3861
Heinz C SchröderERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128 Mainz, Germany. wmueller@uni-mainz.de.ORCID http://orcid.org/0000-0003-0992-6427
Xiaohong WangERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128 Mainz, Germany. wmueller@uni-mainz.de.ORCID http://orcid.org/0000-0003-1796-6314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inorganic polyphosphate (polyP) is a metabolically relevant biopolymer involved in cellular energy storage and ATP-dependent tissue repair, including skin regeneration and wound healing. Here, a Good Manufacturing Practice (GMP)-compliant sodium polyphosphate formulation (Na-polyP-GMP) was developed and evaluated for regenerative applications, with a commercial polyP preparation used for comparison. Na-polyP-GMP exhibited enhanced physicochemical properties, characterized by a narrow, physiologically relevant chain length distribution and a fully amorphous structure, features associated with improved biological performance.

Indexed as

PolyphosphatesRegenerationSkinWound HealingAnimalsCell ProliferationDogsHumansKeratinocytesMicePolyphosphates

Identifiers

PMID42084033
PMCPMC13139896

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.