Evidence map›Paper›PMID 42084032›Full record

ArticleThe Journal of general virology2026

Copper(II) benzyloxychalcone analogues as new potential metallodrugs against SARS-CoV-2 replication.

Igor Andrade Santos, Victoria Riquena Grosche, Laiane Dos Santos Oliveira, Pedro Henrique de Souza Guarda, Gustavo Clauss Rodrigues, Rayany Cristina de Souza, Deborah Cristina Teixeira Alves, Andres Merits, Robinson Sabino-Silva, Dalan Bailey and 3 more

Abstract read
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In one paragraph

Article in The Journal of general virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Igor Andrade SantosInstitute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil.
Victoria Riquena GroscheInstitute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil.
Laiane Dos Santos OliveiraInstitute of Chemistry, University of Campinas, Campinas, Brazil.
Pedro Henrique de Souza GuardaInstitute of Chemistry, University of Campinas, Campinas, Brazil.
Gustavo Clauss RodriguesInstitute of Chemistry, University of Campinas, Campinas, Brazil.
Rayany Cristina de SouzaInnovation Centre in Salivary Diagnostics and Nanobiotechnology, Laboratory of Nanobiotechnology - "Luiz Ricardo Goulart", Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Brazil.
Deborah Cristina Teixeira AlvesInnovation Centre in Salivary Diagnostics and Nanobiotechnology, Laboratory of Nanobiotechnology - "Luiz Ricardo Goulart", Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Brazil.
Andres MeritsInstitute of Bioengineering, University of Tartu, Tartu, Estonia.
Robinson Sabino-SilvaInnovation Centre in Salivary Diagnostics and Nanobiotechnology, Laboratory of Nanobiotechnology - "Luiz Ricardo Goulart", Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Brazil.
Dalan BaileyViral Glycoproteins Group, The Pirbright Institute, Pirbright, Woking, UK.
Camilla AbbehausenInstitute of Chemistry, University of Campinas, Campinas, Brazil.
Mark HarrisSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
Ana Carolina Gomes JardimInstitute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chalcones, a naturally occurring class of molecules found in various plants, serve as both precursors and final products in the biosynthesis of flavonoids. Renowned for their diverse therapeutic actions, chalcones demonstrate anti-inflammatory, antitumoral, antimalarial and antiviral activities. The structure of chalcones allows chemical manipulation, making them attractive for metal coordination, such as with copper, an essential metal for living organisms. Here, we characterize the activity of CuL

Indexed as

Antiviral AgentsBetacoronavirusChalconesCopperSARS-CoV-2Virus ReplicationAnimalsChlorocebus aethiopsHumansMolecular Docking SimulationSpike Glycoprotein, CoronavirusVero CellsAntiviral AgentsChalconesCopperSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antiviralschalconescoronavirus disease 2019 (COVID-19)Cu(II) complexessevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Identifiers

PMID42084032
PMCPMC13141362

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.