Evidence map›Paper›PMID 42083975›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Mouse offspring exposed to preeclampsia/eclampsia-like symptoms exhibit cerebral hypoperfusion and mild cognitive impairment at 2 mo of age.

Karen Saffold, Andrea Tall, A'Kaychia T Lowery, Tyranny Pryor, Maria Jones-Muhammad, Qingmei Shao, Junie P Warrington

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Karen SaffoldProgram in Neuroscience, School of Graduate Studies, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Andrea TallDepartment of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, United States.
A'Kaychia T LoweryProgram in Neuroscience, School of Graduate Studies, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0009-0004-9658-1619
Tyranny PryorDepartment of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0009-0006-0406-5129
Maria Jones-MuhammadProgram in Neuroscience, School of Graduate Studies, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0002-3078-2096
Qingmei ShaoDepartment of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0009-0002-0455-429X
Junie P WarringtonDepartment of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0001-5626-8872

Funding

Center for Psychiatric NeuroscienceP30GM103328 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI STOCKMEIER, CRAIG ALLEN · 2013 to 2017
$5.5M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Mechanisms of Seizure in Pregnancy and PreeclampsiaR56HL159447 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WARRINGTON, JUNIE PAULA · 2021 to 2021
$390k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1 R56 HL159447HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5R25HL145817HHS | NIH | National Institute of General Medical Sciences (NIGMS) P30GM103328NHLBI NIH HHS R25 HL145817NHLBI NIH HHS R56 HL159447NIGMS NIH HHS P30 GM103328University of Mississippi (UM) Startup/Bridge Funds from the Department of Neurology
6 · The paper itself

Abstract

Preeclampsia is a pregnancy complication characterized by high blood pressure and signs of organ damage, after the 20th week of pregnancy. Children born to mothers with preeclampsia or eclampsia (new-onset seizures during pregnancy) are more likely to develop learning and memory deficits and are more susceptible to neurovascular diseases compared with those born from normal pregnancies. The contributing mechanisms are unknown. In this study, we assessed whether exposure to reduced uteroplacental perfusion (RUPP), modeling placental hypoperfusion and preeclampsia, with or without pentylenetetrazol (PTZ) injection (to induce seizures and model eclampsia), results in cognitive impairment, Alzheimer's disease markers, and regional cerebral perfusion changes in adult offspring. On

Indexed as

Behavior, AnimalBrainCerebrovascular CirculationCognitive DysfunctionEclampsiaPre-EclampsiaPrenatal Exposure Delayed EffectsAnimalsDisease Models, AnimalFemaleMaleMaze LearningMiceMice, Inbred C57BLPentylenetetrazolePlacental CirculationPentylenetetrazolecerebral perfusioneclampsialearning and memorypreeclampsiapregnancy

Identifiers

PMID42083975
PMCPMC13431237

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.